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Trichozole (Metronidazole)
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Trichozole

Trichozole eliminates bacteria and other microorganisms that cause infections of the reproductive system, gastrointestinal tract, skin, vagina, and other areas of the body. Antibiotics will not work for colds, flu, or other viral infections. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information.

Other names for this medication:
Aldezol, Amotein, Anabact, Anerobia, Biatron, Dequazol, Diazole, Dirozyl, Elyzol, Flagolin, Flanizol, Florazole, Fortagyl, Gynotran, Metco, Metral, Metrobac, Metrocreme, Metrodal, Metrofusin, Metrozine, Mtrocol, Mtronidazole, Nidazea, Nidazole, Norzol, Padet, Pharmaflex, Repligen, Rosaced, Rosalox, Rozamet, Stomorgyl, Taremis, Trichazole, Trichopol, Triconex, Vandazole, Varizil, Zidoval, Zobacide

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Also known as: Metronidazole

Description

Trichozole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Trichozole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In elderly patients, the pharmacokinetics of metro- nidazole may be altered, and, therefore, monitor- ing of serum levels may be necessary to adjust the metronidazole dosage accordingly.

Overdose

In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Trichozole overdose, Trichozole infusion should be discontinued. Patients should be treated symptomatically.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Trichozole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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