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Toraseptol

Azalides are a class of macrolide antibiotics which contain a nitrogen in the macrolide ring. This imparts different pharmacokinetic properties and is associated with greater stability of the molecule. One such Azalide is the antibiotic Toraseptol. This medication is a macrolide antibiotic used for various bacterial infections such as infections of the middle ear, throat, bronchus, sinuses, skin and soft tissue. It is also useful in treating pneumonia, typhoid, gonorrhoea, granuloma inguinale and chancroid. It prevents bacterial growth.

Other names for this medication:
Arzomicin, Azalid, Azatril, Azenil, Azibiot, Azicin, Azicine, Azimax, Azinil, Azinom, Azirox, Azithin, Azithrox, Azitro, Azitrotek, Azitrox, Azomex, Aztrin, Bactexina, Bactrazol, Binozyt, Doromax, Fabramicina, Goxil, Ilozin, Imbys, Macrozit, Medimacrol, Nifostin, Oranex, Pretir, Rarpezit, Ricilina, Sitrox, Talcilina, Tridosil, Tritab, Trozocina, Ultreon, Vinzam, Zemycin, Zertalin, Zicho, Zirocin, Zithrocin, Zithromac, Zitrocin, Zitroneo, Zival

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Also known as: Azithromycin

Description

Toraseptol is used to treat many different types of infections caused by bacteria, such as respiratory infections, skin infections, ear infections, and sexually transmitted diseases. In children, it is used to treat middle ear infection, pneumonia, tonsillitis, and strep throat.

Toraseptol, a semisynthetic antibiotic belonging to the macrolide subgroup of azalides, is used to treat STDs due to chlamydia and gonorrhea, community-acquired pneumonia, pelvic inflammatory disease, pediatric otitis media and pharyngitis, and Mycobacterium avium complex (MAC) in patients with advanced HIV disease. Similar in structure to erythromycin. azithromycin reaches higher intracellular concentrations than erythromycin, increasing its efficacy and duration of action.

Bioavailability is 37% following oral administration. Absorption is not affected by food. Azithromycin is extensively distributed in tissues with tissue concentrations reaching up to 50 times greater than plasma concentrations. Drug becomes concentrated within macrophages and polymorphonucleocytes giving it good activity against Chlamydia trachomatis.

Dosage

Dosage of Toraseptol is setted individually according to nosology, disease severity and sensitivity of the pathogen. Dosage for adults for oral administration is 0.25-1 g 1 time/day; for children - 5-10 mg/kg 1 time/day. The duration of administration is 2-5 days.

Overdose

Seek emergency medical attention if you think you have used too much of this medicine. Symptoms of an Toraseptol overdose may include nausea, vomiting, diarrhea, and stomach discomfort.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) and away from excess moisture and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Toraseptol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not use Toraseptol if you are allergic to azithromycin and other macrolides. Do not take Toraseptol at the same time as taking antacids containing magnesium or aluminum. Exercise caution with Toraseptol if you are pregnant or are a nursing mother. If you have liver or kidney disease, Long QT syndrome or heart rhythm problems, consult your doctor before taking Toraseptol. Exercise caution if you are also taking cyclosporine (Neoral, Sandimmune), anticoagulants ('blood thinners') such as warfarin (Coumadin), terfenadine (Seldane), digoxin (Lanoxin), dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar), phenytoin (Dilantin), medications that suppress your immune system, nelfinavir (Viracept). Exercise caution with Toraseptol usage if you are allergic to erythromycin (E.E.S., E-Mycin, Erythrocin), dirithromycin (Dynabac), clarithromycin (Biaxin) or azithromycin. Avoid excessive exposure to sunlight as Toraseptol makes skin sensitive to sunlight. Take care to protect skin from the sun. It can be dangerous to stop taking Toraseptol suddenly.

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The ventral hippocampus is the embryonic origin for adult neural stem cells in the dentate gyrus. The specific activities for the removal of 5-foU and 5-hmU were comparable with that for thymine glycol. The presence of osteocalcin in bone matrix may alter bone remodeling by promoting osteoclast activity. Since the cAMP and the mitogen-activated protein kinase (MAPK) pathways can modulate the growth of RTEc, we studied whether two cAMP elevating agents, isoproterenol flagyl antibiotic strengths and 8-bromo-cAMP, would modulate basic fibroblast growth factor (bFGF) induction of MAPK activity (ERK-2) and cell proliferation in human renal proximal tubular epithelial cells (RPTEc) and Madin-Darby canine kidney cells (MDCK clone EI1). Heart rate variability during massive hemorrhage and progressive hemorrhagic shock in dogs. Longitudinal analyses of rheumatoid factor (RF), antinuclear antibodies (ANA), anti-double-stranded DNA antibodies and serum IL-10 (ELISA) and the typing of HLA DR and DQ alleles were performed. All uremic aortae stained positively, but nitrotyrosine was not present in any control aortae.

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The effect of aging of isolated chloroplasts of two chilling-sensitive (CS) and three chilling-resistant (CR) plants on the inactivation of oxygen evolution and accumulation of free fatty acids (FFA) was studied at 30 degrees C, pH 5.5 or 7.0, in the absence or presence of either sorbitol or NaCl. Finally, treatment of cells with leptomycin B, an exportin inhibitor, results in the nuclear accumulation of Ste11p. This conclusion was based on experiments in which environmentally sensitive, sulfhydryl-reactive fluorophores were site-selectively incorporated into wild-type and mutant beta2-adrenergic receptors purified from Sf-9 insect cells. Common and unique regions, as well as previously known and novel QTLs, underlying fruit morphology in tomato were identified. These data provide timely information concerning the contributions of the Nrf2-ARE pathway in ALS disease progression. Congenital cysts of the third and fourth pharyngeal pouches or pyriform sinus cysts. In conclusion, rat strains play a significant role in the response to acute and chronic administration of MPD. The combination of antibodies MSgp7 and MSgp8 with flow cytometry could be applied to other guinea pig experimental models to quantitate the expression of MHC class II antigens on T cells to determine their putative value in disease manifestation.

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