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Respexil (Norfloxacin)
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Respexil

Respexil is a fluoroquinolone antibiotic. Respexil works by blocking DNA gyrase enzyme, which is responsible for production and repair of bacterial DNA. Blocking of DNA gyrase leads to bacteria death and prevents worsening of infection.

Other names for this medication:
Ambigram, Baccidal, Bacfamil, Bactracid, Baxicin, Esclebin, Floxamed, Floxamicin, Floxatral, Floxatrat, Fluseminal, Lemorcan, Lexiflox, Menorox, Naflox, Nalion, Noprose, Norax, Norcozine, Norflogen, Norflohexal, Norflok, Norfloxacin, Normax, Norocin, Noroxine, Norsol, Notler, Pistofil, Renor, Ritromine, Taflox, Uriflox, Urofos, Uroxacin, Utibid, Vefloxa, Zoroxin

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Cipro, Levaquin, Cefixime, Chloromycetin, Cleocin, Zithromax

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Also known as: Norfloxacin

Description

Respexil comes as a tablet to take by mouth. It is usually taken twice a day for 3 to 28 days. The length of treatment depends on the type of infection being treated. Your doctor will tell you how long to take Respexil. Take Respexil at around the same times every day and try to space your doses 12 hours apart. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take Respexil exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.

Take Respexil at least 1 hour before or 2 hours after meals or after drinking milk or eating dairy products.

Swallow the tablets with a full glass of water.

You should begin to feel better during the first few days of your treatment with Respexil. If your symptoms do not improve or if they get worse, call your doctor.

Take Respexil until you finish the prescription, even if you feel better. Do not stop taking Respexil without talking to your doctor unless you experience certain serious side effects listed in the IMPORTANT WARNING or SIDE EFFECT sections. If you stop taking Respexil too soon or if you skip doses, your infection may not be completely treated and the bacteria may become resistant to antibiotics.

Respexil is also sometimes used to treat certain infections of the stomach and intestines. Talk to your doctor about the risks of using this medication for your condition.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Dosage

Before taking Respexil tell your doctor and pharmacist if you are allergic or have had a severe reaction to Respexil; other quinolone or fluoroquinolone antibiotics such as ciprofloxacin (Cipro), gatifloxacin (Tequin) (not available in the U.S.), gemifloxacin (Factive), levofloxacin (Levaquin), lomefloxacin (Maxaquin) (not available in the U.S.), moxifloxacin (Avelox), nalidixic acid (NegGram), ofloxacin (Floxin), and sparfloxacin (Zagam) (not available in the U.S.), or any other medications.

Tell your doctor and pharmacist what other prescription and nonprescription medications, vitamins, herbal products, and nutritional supplements you are taking or plan to take. Be sure to mention the medications listed in the IMPORTANT WARNING section and any of the following: other antibiotics; anticoagulants ('blood thinners') such as warfarin (Coumadin, Jantoven); certain antidepressants; antipsychotics (medications to treat mental illness); caffeine or medications that contain caffeine (Excedrin, NoDoz, Vivarin, others); cisapride (Propulsid) (not available in the U.S.); clozapine (Clozaril, Fazaclo); cyclosporine (Gengraf, Neoral, Sandimmune); diuretics ('water pills'); erythromycin (E.E.S, E-Mycin, Erythrocin, others); glyburide (DiaBeta, in Glucovance, Micronase, others); certain medications for irregular heartbeat such as amiodarone (Cordarone), procainamide (Procanbid), quinidine, and sotalol (Betapace, Betapace AF, Sorine); nitrofurantoin (Furadantin, Macrobid, Macrodantin); probenecid (in Col-Probenecid, Probalan); nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen (Advil, Motrin, others) and naproxen (Aleve, Naprosyn, others); ropinirole (Requip); tacrine (Cognex); theophylline (Elixophyllin, Theo-24, Uniphyl, others); and tizanidine (Zanaflex). Your doctor may need to change the doses of your medications or monitor you carefully for side effects.

If you are taking antacids containing aluminum hydroxide or magnesium hydroxide (Maalox, Mylanta, Tums, others), didanosine (Videx) sucralfate (Carafate), or supplements or multivitamins that contain iron or zinc, take these medications 2 hours before or 2 hours after you take Respexil.

Tell your doctor if you or anyone in your family has or has ever had a prolonged QT interval (a rare heart problem that may cause irregular heartbeat, fainting or sudden death) or an irregular heartbeat and if you have or have ever had nerve problems, a low level of potassium in your blood, a slow heartbeat, chest pain, seizures, myasthenia gravis (condition that causes weakness of certain muscles), cerebral arteriosclerosis (narrowing of blood vessels in or near the brain that can lead to stroke or mini-stroke), or glucose-6-phosphate dehydrogenase (G-6PD) deficiency (an inherited blood disorder).

Tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking Respexil, call your doctor.

You should know that this medication may cause dizziness, lightheadedness, and tiredness. Do not drive a car, operate machinery, or participate in activities requiring alertness and coordination until you know how Respexil affects you.

Plan to avoid unnecessary or prolonged exposure to sunlight or ultraviolet light (tanning beds and sunlamps) and to wear protective clothing, sunglasses, and sunscreen. Respexil may make your skin sensitive to sunlight or ultraviolet light. If your skin becomes reddened, swollen, or blistered, call your doctor.

Overdose

If you overdose Generic Respexil and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Side effects

The most common side effects associated with Respexil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Taking norfloxacin increases the risk that you will develop tendinitis (swelling of a fibrous tissue that connects a bone to a muscle) or have a tendon rupture (tearing of a fibrous tissue that connects a bone to a muscle) during your treatment or for up to several months afterward. These problems may affect tendons in your shoulder, your hand, the back of your ankle, or in other parts of your body. Tendinitis or tendon rupture may happen to people of any age, but the risk is highest in people over 60 years of age. Tell your doctor if you have or have ever had a kidney, heart, or lung transplant; kidney disease; a joint or tendon disorder such as rheumatoid arthritis (a condition in which the body attacks its own joints, causing pain, swelling, and loss of function); or if you participate in regular physical activity. Also tell your doctor if you have ever had any tendon problems during or after your treatment with norfloxacin or another quinolone or fluoroquinolone antibiotic. Tell your doctor and pharmacist if you are taking oral or injectable steroids such as dexamethasone (Decadron, Dexpak), methylprednisolone (Medrol), or prednisone (Sterapred). If you experience any of the following symptoms of tendinitis, stop taking norfloxacin, rest, and call your doctor immediately: pain, swelling, tenderness, stiffness, or difficulty in moving a muscle. If you experience any of the following symptoms of tendon rupture, stop taking norfloxacin and get emergency medical treatment: hearing or feeling a snap or pop in a tendon area, bruising after an injury to a tendon area, or inability to move or bear weight on an affected area.

Taking norfloxacin may worsen muscle weakness in people with myasthenia gravis (a disorder of the nervous system that causes muscle weakness) and cause severe difficulty breathing or death. Tell your doctor if you have myasthenia gravis. Your doctor may tell you not to take norfloxacin. If you have myasthenia gravis and your doctor tells you that you should take norfloxacin, call your doctor immediately if you experience muscle weakness or difficulty breathing during your treatment.

Talk to your doctor about the risks of taking norfloxacin.

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CYP2B1 and CYP2B2 mRNAs were significantly induced at 6 h after each dose in group A-75 (maximum of 2100-fold and 60-fold after the third dose, respectively), whereas the mRNA levels measured at 6 h postadministration in group A-150 were 1,490-fold and 36-fold after the second dose. Fatal hepatic failure secondary to acute herpes simplex virus infection. However, the link between endothelial AT binding and anti-inflammatory AT effects remains to be established in vivo, although heparin has been shown to counteract anti-inflammatory AT effects. Graphene based quantum dots and antidots are two nanostructures of primary importance for their fundamental physics and technological applications, particularly in the emerging field of graphene-based nanoelectronics and nanospintronics. Prevention of massive postoperative cicatrix formation on the peripheral nerves. It also argued that the rural health sector reform in China is really a passive response to the changed rural socio-economic conditions rather than an active action aimed at improving the health status of the rural population. A new one-dimensional mixed-culture biofilm model was derived based on a hypothesis that each particulate component would have different space occupancy within biofilm.

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