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Promuba (Metronidazole)

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Promuba belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

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Also known as: Metronidazole


Promuba (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Promuba is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


Promuba 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Promuba and 250 on the other side; bottles of 50, 100, and 2,500. Promuba 500-mg tablets are oblong, blue, film coated, with Promuba debossed on one side and 500 on the other side; bottles of 50, 100, and 500.


Single oral doses of Promuba, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Promuba has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Promuba overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Promuba are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Hypersensitivity. Promuba Tablets is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives. In patients with trichomoniasis, Promuba Tablets is contraindicated during the first trimester of pregnancy.

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