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Olcin (Levofloxacin)
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Olcin

Olcin is used to treat a variety of bacterial infections. This medication belongs to a class of drugs known as quinolone antibiotics. It works by stopping the growth of bacteria. This antibiotic treats only bacterial infections. It will not work for viral infections (such as common cold, flu). Using any antibiotic when it is not needed can cause it to not work for future infections.

Other names for this medication:
Anlev, Benfloxin, Corbic, Corvox, Elequine, Floxator, Floxlevo, Isofloxx, Ledric, Leeflox, Leflokin, Leflox, Lefloxin, Lekuicin, Levin, Levocine, Levoday, Levofloxacin, Levofloxacina, Levofloxacino, Levofloxacinum, Levogen, Levoking, Levomax, Levoprolin, Levoquinox, Levores, Levotac, Levoxetina, Levunid, Locin, Mosardal, Nevotek, Nislev, Novacilina, Priflox, Prolecin, Quinix, Tamiram, Tavaloxx, Tavanic, Teraquin, Tevox, Truxa, Ultraquin, Volox, Voxin, Zenilev

Similar Products:
Suprax, Cleocin, Chloromycetin, Floxin, Ceftin, Omnicef, Duricef, Cipro, Keflex, Amoxil

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Also known as: Levofloxacin

Description

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Olcin and other antibacterial drugs, Olcin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

Olcin Tablets/Injection and Oral Solution are indicated for the treatment of adults (≥18 years of age) with mild, moderate, and severe infections caused by susceptible strains of the designated microorganisms in the conditions listed in this section. Olcin Injection is indicated when intravenous administration offers a route of administration advantageous to the patient (e.g., patient cannot tolerate an oral dosage form).

Dosage

Rapid or bolus intravenous infusion of Olcin has been associated with hypotension and must be avoided. Olcin Injection should be infused intravenously slowly over a period of not less than 60 or 90 minutes, depending on the dosage. Olcin Injection should be administered only by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration.

Overdose

Overdose of the drug should be strictly avoided and if anyone has accidentally taken the overdose of the drug, then the victim should be provided with emergency medical help. Overdose victim can also consult to their local poison helpline. Some of the overdose symptoms include loss of coordination, drooping eyelids, weakness, decreased activity, trouble breathing, sweating, tremors, or seizure.

Storage
Side effects

The most common side effects associated with Olcin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Risk of tendinitis and tendon rupture is increased. This risk is further increased in older patients usually over 60 years of age, in patients taking corticosteroids, and in patients with kidney, heart and lung transplants. Discontinue if pain or inflammation in a tendon occurs.

Anaphylactic reactions and allergic skin reactions, serious, occasionally fatal, may occur after first dose.

Hematologic (including agranulocytosis, thrombocytopenia), and renal toxicities may occur after multiple doses.

Hepatotoxicity: Severe, and sometimes fatal, hepatoxicity has been reported. Discontinue immediately if signs and symptoms of hepatitis occur.

Central nervous system effects, including convulsions, anxiety, confusion, depression, and insomnia may occur after the first dose. Use with caution in patients with known or suspected disorders that may predispose them to seizures or lower the seizure threshold.

Clostridium difficile-associated colitis: evaluate if diarrhea occurs.

Peripheral neuropathy: discontinue if symptoms occur in order to prevent irreversibility.

Prolongation of the QT interval and isolated cases of torsade de pointes have been reported. Avoid use in patients with known prolongation, those with hypokalemia, and with other drugs that prolong the QT interval.

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NF-kappaB regulates the transcriptional of genes important for tumor invasion, metastasis and chemoresistance. In contrast to vascular plants, the moss Physcomitrella patens has only 105 PPR genes. The in vitro skin permeability of each catechin derivative was determined using side-by-side diffusion of cells. To explain the origin of stereoselective preference, an S(N)i mechanism was proposed and corroborated by computational calculations. The newest generation of influenza antiviral agents are neuraminidase inhibitors--zanamivir and oseltamivir, effective against both virus types.

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Neuromyelitis optica (NMO) is an inflammatory disease that affects the optic nerve and spinal cord. Coordinated observation of various factors in the inflammatory system and their relations shows that the levels of proamidase in granuloma pouch fluid in carrageenin-induced inflammation increase during the healing process whereas the proamidase shows (1) remarkably low values in rats injected with high doses of carrageenin, (2) low values in the earlier stages of inflammation with tissue damage (high values of fluid lipid peroxide and lactate dehydrogenase) and with phagocytosis (high values of fluid peroxidase and beta-glucuronidase), and (3) high values in the later stages where wound healing is progressing (high values of protein in plasma, fluid and granuloma pouch tissue and low values of fluid volume, fluid peroxidase, beta-glucuronidase and pouch tissue weight). Sponge biopsy in the diagnosis of cancer of the skin and oral mucosa. Prompt recognition of complication and its treatment remedied the situation. This study examined the relationship between breakfast cereal consumption and non-milk extrinsic sugars (NMES) intake and the possible implications of this for caries in preschool children. Microscale enzymatic optical biosensors using mass transport limiting nanofilms. We report a novel form of the gaseous state at the interface of water and highly oriented pyrolytic graphite (HOPG) that is induced by local supersaturation of gas. The mean age of the patients at the time of the index operation was fifty-six years. Furthermore, as a consequence of large sequencing programs the complete genomic sequence has become available for an increasing number of microorganisms.

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Dentists traditionally think of periodontal treatment as a means of saving the teeth while leaving the patient with an esthetic problem. This is a retrospective review of 12 cases of scaphoid nonunion in 12 skeletally immature patients treated with a uniform approach consisting of open reduction, iliac crest bone grafting and Herbert screw fixation. WT homo-oligomeric complexes were secreted in the extracellular media of both cell lines whereas the Q368X and K423E mutant/mutant homomultimers and heteromeric WT/mutant oligomers remained sequestered intracellularly. To identify and describe individual and tooth-specific factors associated with the incidence or the persistence of apical periodontitis (AP) in a general population. Simple models of continuous and periodic protocols of combined therapy are implemented. A novel histone deacetylase 6-selective inhibitor suppresses synovial inflammation and joint destruction in a collagen antibody-induced arthritis mouse model. Lower limb compression bandaging is effective in preventing signs and symptoms of seating-induced postural hypotension. Quantitative evaluation is performed on biological datasets, and shown to yield a substantial decrease in convergence time, with no loss of model quality.

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Barriers and facilitators to recovering from e-prescribing errors in community pharmacies. Complex hygiene assessment and control of work conditions are difficult due to the lack of hygiene standards for micro-organisms and endotoxins in the air of the workplace. Occurrence of spinal pain syndromes in a group of apparently healthy and physically fit sportsmen (orienteers). Concomitant with increased intestinal mass, food and water intake increased significantly in Stz-diabetic animals. The clinical utility of corticomotor evoked potentials (CMEPs) as a method of evaluating and monitoring patients with spinal cord disorders is being intensively studied. Four different filters were evaluated using a motion-free canine study. Pneumonia due to non-typhoidal Salmonella is a rarely reported entity. Nevertheless it is not only important to discuss the model type, but also the type of kinetics assumed in the interior of the beads, as well as the internal structure, the boundary conditions related to bead shredding and cell escape and finally, geometrical effects.

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Future work with this technique will provide important information about mouse atrial electrophysiology and how it relates to that of larger mammals. Isometric tubular vacuolization is a common finding in renal transplant biopsy specimens of patients who receive low-dose IVIG and in many cases is likely to be related, at least in part, to IVIG. Since low levels of p53 have been observed in papillomavirus-transformed keratinocyte cell lines, it was speculated that degradation of p53 by E6 contributes to papillomavirus-associated growth deregulation. Effect of calcium channel blockers alone and in combination with antiglaucoma medications on intraocular pressure in the primate eye. Isolated vertebral sarcoidosis--a rare differential diagnosis of osteolitic spinal cord lesions.

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The best treatment for MFHs is surgery with radical excision of the tumor. The oncogenesis induced by the monkey SA7(C8) adenovirus in CBA/Ca mice has shown that immune responses to embryonal antigens are formed at early stages of the latent period and are preserved for a long time reaching the maximum by the 30th day of the latent period. Discrimination of these three models is not of great importance. Mesocestoides infection in captive olive baboons (Papio cynocephalus anubis). Orientation distribution of highly oriented type I collagen deposited on flat samples with different geometries. The importance of work-facilitating devices and working aids in the vocational rehabilitation of the physically handicapped and the status of their performance in training places for the disabled.

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These results suggest that the levels of Al-oxalate complexes increased in response to an increase in the Al level, implying that oxalate is a key Al-chelating compound in the mechanism of Al detoxification in the tea root. Study of changes in behavior of Parisian intravenous drug addicts. In the case of ischemia lasting for more than 6 hours, the anti-actin antibody reaction had disappeared, corresponding to the disappearance of the TTC reaction. The effectiveness of psychoeducation and systematic desensitization to reduce test anxiety among first-year pharmacy students. It appears that each method of fertilization has a unique pattern of gene expression and development. From a study of the deformities of each layer of the abdominal wall, we have categorized five types of abdominoplasties. Influence of heme oxygenase inhibitors on the basal tissue enzymatic activity and smooth muscle relaxation of internal anal sphincter. Hemopexin (Hx) functions as a major heme scavenging protein in blood plasma and as such circulates without heme bound. To test whether unexpected lateral mass placement increases low back loading and trunk movement when subjects are lifting a mass in upright posture.

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The influence of body weight on lipoprotein lipids in patients with polycystic ovary syndrome. There were 79 neonatal deaths and 54 NNT deaths with NNT mortality rate of 20.6/1000 live births. Provision of MTMS involves a patient-centered model for delivery of care. Phase II study of vinblastine and doxorubicin in advanced renal cell carcinoma. Characterization of METH-1/ADAMTS1 processing reveals two distinct active forms. Implants may be placed penetrating the oral mucosa (1-stage procedure) or can be completely buried under the oral mucosa (2-stage procedure) during the healing phase of the bone at the implant surface. msbA from Escherichiacoli (msbA(Ec)) could not cross complement the msbA merodiploid cells of P. Management of adult splenic injuries in Ontario: a population-based study.

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Thyroid carcinoma cells are resistant to FAS-mediated apoptosis but sensitive to tumor necrosis factor-related apoptosis-inducing ligand. During advanced embryogenesis, either PRX2-positive cells become condensed in the border of SOX2-positive cells or PRX1 and/or PRX2 become co-localized with SOX2. In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions. Similar results were obtained with m(1) and m(3) muscarinic receptors in HEK293T cells and with the B(2)R in human and mouse fibroblasts, indicating a general mechanism in signaling toward the ERK cascade. The only free thiol group of bovine serum albumin (BSA) was coupled in a high yield with some novel thiol-reactive clenbuterol analogues.

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These findings suggest that combined treatment with vorinostat and sorafenib synergistically induces apoptosis in CML cells through a process that involves Mcl-1 down-regulation and inhibition of p21(CIP1) induction. Evaluation of potential for reuse of industrial wastewater using metal-immobilized catalysts and reverse osmosis. This is the first report of bottom-up, amended, and simple dosing of TacOD in LT. Median frequency slopes levaquin oral dosing of Iliocostalis and Multifidus muscles as well as holding time during Biering-Sorensen test were measured using surface electromyography. lipophilic drugs, solvents, alcohols, hormonal steroids and biocides, these DNA-binding proteins transform xenobiotic or steroid stimuli to coordinated activations of gene transcription-programs for ALAS1 and apo-cytochromes P450 (apo-CYPs), thus effecting the formation of xenobiotic-metabolizing cytochrome P450 enzymes. Neurosurgical collaboration in the treatment of various juvenile hemorrhagic fibroangiomas.

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Reversed-phase high-performance liquid chromatography combined with on-line UV diode array, FT infrared, and 1H nuclear magnetic resonance spectroscopy and time-of-flight mass spectrometry: application to a mixture of nonsteroidal antiinflammatory drugs. Risk factors for the nasopharyngeal carriage of respiratory pathogens by Portuguese children: phenotype and antimicrobial susceptibility of Haemophilus influenzae and Streptococcus pneumoniae. The question of how animal studies should be designed, conducted, and analyzed remains underexposed in societal debates on animal experimentation. Polyphenols in cocoa, including monomeric flavanols, as well as polymeric proanthocyanidins, may play a role in these observed beneficial effects. Daily rhythm of the secretion of aldosterone in patients with hypertension. The AmphiDelta-expressing cells delaminating from the ectoderm apparently migrate beneath it as they begin differentiating into probable sensory neurons, suggesting a scenario for the evolutionary origin of the placode-derived neurons of vertebrate cranial ganglia. Glial cell line-derived neurotrophic factor-like immunoreactivity in the cerebella of normal subjects and patients with multiple system atrophy.

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