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Minegyl (Metronidazole)
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Minegyl

Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria. Treating certain infections caused by bacteria or amoebas. It may also be used for other conditions as determined by your doctor.

Other names for this medication:
Amodis, Anerobia, Biatron, Clont, Dazotron, Emedal, Etronil, Flagolin, Fortagyl, Ginkan, Medamet, Menilet, Metazole, Metrajil, Metrin, Metrocream, Metrol, Metrolotion, Metrolyl, Metronidazol, Metronour, Metryl, Metsina, Molazol, Mtronidazole, Nidazole, Orogyl, Pharmaflex, Protogyl, Protozol, Rhodogil, Rosaced, Rosalox, Rosasol, Rozacrme, Rozagel, Tismazol, Torgyl, Trichex, Trichodazol, Tricodazol, Trikozol, Vagimid, Vandazole, Zidoval

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Also known as: Metronidazole

Description

Minegyl (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Minegyl is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In the Female. One-day treatment – two grams of Minegyl, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Overdose

Single oral doses of Minegyl, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Minegyl has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Minegyl overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store below 77 degrees F (25 degrees C) and protect from light.

Side effects

The most common side effects associated with Minegyl are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

As a rule, the usual duration of therapy with i.v Metronidazole or other imidazole derivatives is usually less than 10 days. This period may only be exceeded in individual cases after a very strict benefit-risk assessment. Only in the rarest possible case should the treatment be repeated. Limiting the duration of treatment is necessary because damage to human germ cells cannot be excluded.

Intensive or prolonged Metronidazole therapy should be conducted only under conditions of close surveillance for clinical and biological effects and under specialist direction. If prolonged therapy is required, the physician should bear in mind the possibility of peripheral neuropathy or leucopenia. Both effects are usually reversible.

In case of prolonged treatment, occurrence of undesirable effects such as paraesthesia, ataxia, dizziness and convulsive crises should be checked. High dose regimes have been associated with transient epileptiform seizures.

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Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures. Thirty-one DP patients (ulnar, tibial, and peroneal nerves) and 66 RAD patients (peroneal nerve) were investigated. Pig neutrophil azurophil granules were less dense than the specific granules, unlike those from neutrophils of most other mammalian species. From the neurologic standpoint, it offers an opportunity to consolidate the complications produced by leukemias, lymphomas, and plasma cell dyscrasias. Homosexuality does not cause acquired immunodeficiency syndrome.

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Foot and mouth disease risk assessment in Mongolia--local expertise to support national policy. The results of these studies suggest that HIV-1 has access to both tRNAMet for selection as the replication primer and supports a co-ordination between primer selection, translation and encapsidation during virus replication. You are lost without a map: Navigating the sea of protein structures. Ventricular repolarization in a rat model of global heart failure. An R-program, implementing the algorithm, is freely available at http://bioinfo.thep .lu.se/MissingValues2Dgels.html.

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Brown adipose tissue heat production in heat acclimated and perchlorate treated rats. Treatment of congestive heart failure a neuroendocrine disorder. Call taker triage of calls to the 112 emergency number, can be error prone because rapid decisions must be made based on limited information. Fifteen-year minimum follow-up of a prostate brachytherapy series: comparing the past with the present. These data suggest that the central melanocortin system regulates not only energy intake and expenditure, but also processes related to energy partitioning, as indicated by effects on insulin release and peripheral insulin responsiveness. Because the meristems and the three fundamental tissues formed during embryogenesis are renewed and extended throughout the life of the plant, with some exceptions, most genes expressed in the embryo are also expressed during postgermination development. (Barbosa, Carmody, Gainey, Payne,Plichta, Sajko, Vandecar-Burdin, 2005) Utilizing a variety of research methodologies, the study examined the response by law enforcement, criminal justice, medical and social service agencies. Outcomes evaluated included implant survivorship, hip scores, activity levels, and complication rates. This group consisted of the 5 contralateral normal eyes of 5 patients with unilateral PHPV in the fellow eye, both eyes of one patient with uncomplicated unilateral cataracts, the affected eye of one patient with unilateral uncomplicated cataract, the affected eye of one patient with isolated retinal coloboma, and 13 normal eyes of 7 young adults. With this approach, an uncertainty factor of 1000 applied to the no-observed-adverse-effect level in the NTP bioassay yielded a safe exposure level of 45-56 micrograms/kg/day.

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Symptomatic improvement and reduction in the degree of relative enophthalmos, hypoglobus, and upper eyelid sulcus deformity. The epithelial to mesenchymal transition (EMT) generates tumor cells having stem cell characteristics with phenotypes similar to cancer stem cells (CSCs). This brief report presents and comments pictures taken during fieldwork carried out in drug scenes, located in the metropolitan area of Rio de Janeiro, Brazil, as part of the National Crack Cocaine Survey, 2011-2013. Postcataract endophthalmitis: incidence and microbial isolates in a United Kingdom region from 1996 through 2004. The Jarisch-Herxheimer reaction (JHR) is a transient immunological phenomenon seen commonly in patients during treatment for syphilis, and it manifests clinically with short-term constitutional symptoms such as fever, chills, headache and myalgias, besides exacerbation of existing cutaneous lesions. Free fatty acid enhancement of cation-induced fusion of liposomes: synergism with synexin and other promoters of vesicle aggregation. The phospholipase A2 (PLA2) activities at both days in culture were qualitatively similar and typical of the recently described high-molecular-mass cytosolic PLA2 (cPLA2), but activity in day 7 cytosol was threefold greater than that present in day 2 cytosol. In the development of assistive devices, such as functional electrical stimulators, it is important to make the device as straightforward to use as possible. They most often affect the area of the head and neck, occur with greater frequency among women and Caucasians, and can be found in the oral cavity-especially on the lips, tongue, or mucosa. We investigated the accuracy of 3D image registration using markers that are repeatedly applied to external anatomical landmarks on the head.

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This study investigates outcome of scoliosis treatment for 11 children with Angelman syndrome (AS), with particular focus on activity, participation and the musculoskeletal factors that may affect these outcomes. Immunosuppressive effects of benzidine in mice: evidence of alterations in arachidonic acid metabolism. Although these studies remain at an early stage together these findings strongly suggest that, as in adults, Tpo is the major regulator of platelet homeostasis in the fetus and neonate. Thermotropic behavior of lipids and the morphology of Yersinia pseudotuberculosis cells with a high content of lysophosphatidylethanolamine. These MR findings, and corresponding neuroradiologic data disclosed by the review, indicate that homolateral hemiatrophy occasionally occurs in a subgroup of patients with progressive facial hemiatrophy. In these cases, tolerance to tianeptine and the symptoms of depreviation in absence of the drug have been seen, and the history of dependence or abuse of any drug or alcohol, treatment for mood and/or personality disorders are mentioned as possible risks for the dependence to tianeptine. Patients with sclerosing cholangitis, following septic shock, represent a new variant of vanishing bile duct disorders.

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