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Metrozole (Metronidazole)
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Metrozole

Metrozole belongs to the class of medicines known as antibiotics. It works by killing bacteria or preventing their growth. However, this medicine will not work for colds, flu, or other virus infections.

Other names for this medication:
Amebidal, Amrizole, Asuzol, Biozyl, Clont, Collazole, Colpofilin, Dazotron, Dequazol, Flagemed, Flazole, Giardyl, Ginkan, Gnostol, Gynomix, Mecozol, Metrocev, Metrodal, Metroderme, Metrol, Metrolag, Metrolyl, Metronidazol, Metronidazole, Metronidazolum, Metrosa, Metrozol, Negazole, Nidagel, Orogyl, Riazole, Rodogyl, Rozex, Rupezol, Stomorgyl, Taremis, Trichazole, Trichostatic, Trichozole, Tricofin, Tricozyl, Zidoval

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Also known as: Metronidazole

Description

Metrozole (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metrozole is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

Metrozole 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Metrozole and 250 on the other side; bottles of 50, 100, and 2,500. Metrozole 500-mg tablets are oblong, blue, film coated, with Metrozole debossed on one side and 500 on the other side; bottles of 50, 100, and 500.

Overdose

Single oral doses of Metrozole, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Metrozole has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Metrozole overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Metrozole are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

To reduce the development of drug-resistant bac- teria and maintain the effectiveness of Metrozole and other antibacterial drugs, Metrozole should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria.

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Older age is an important factor in preparing travelers owing not only to physiologic changes and the increased probability of underlying medical conditions and prescription medications but also to immune status with regard to naturally acquired immunity versus immunization for vaccine-preventable diseases. Methods are described for rapid and economical production of large quantities of foot-and-mouth disease virus in stationary cultures of trypsin-dispersed bovine kidney cells in a simple medium. Bootstrap-based statistical thresholding for MEG source reconstruction images. Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients. A more complex model is proposed in which drugs and metabolites are incorporated into hair during formation of the hair shaft (via diffusion from blood to the actively growing follicle), after formation (via secretions of the apocrine and sebaceous glands), and after hair has emerged from the skin (from the external environment).

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Development of angiogenesis inhibitory combination therapies for treatment of renal cell carcinoma. In vitro establishment of human fibroblasts of lysosomal diseases, GM1-gangliosidosis and Sandhoff disease, by transformation with origin-minus SV40 DNA. The role of rpoS, hmp, and ssrAB in Salmonella enterica Gallinarum and evaluation of a triple-deletion mutant as a live vaccine candidate in Lohmann layer chickens. The aim of this study is to further examine this issue by analyzing a large sample of psychotic probands and their first-degree relatives. A modification of cryosurgery for the management of elevated bleb. Age group-specific and standardised overall and truncated (50-79 years old) rates were calculated by the direct method (European standard population).

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