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Metrozine (Metronidazole)

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Metrozine is an antibiotic and antiprotozoal medication. It is used either alone or with other antibiotics to treat pelvic inflammatory disease, endocarditis, and bacterial vaginosis. It is effective for dracunculiasis, giardiasis, trichomoniasis, and amebiasis.

Other names for this medication:
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Also known as: Metronidazole


Metrozine (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metrozine is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


In elderly patients, the pharmacokinetics of metro- nidazole may be altered, and, therefore, monitor- ing of serum levels may be necessary to adjust the metronidazole dosage accordingly.


Single oral doses of Metrozine, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Metrozine has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Metrozine overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Metrozine are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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Concurrent infection of a cat with cowpox virus and feline parvovirus. We report the 33rd case, a 41-year-old male who presented with pain in the nape of the neck. A fast global fitting algorithm for fluorescence lifetime imaging microscopy based on image segmentation. Paracoccidioidic granulomatosis (observation of the causative agent, by phase contrast microscopy). Integrated MELD may be a more accurate predictor of operative mortality in cirrhotic patients undergoing extrahepatic surgery than CTP and other MELD-Na based indices. Our results also establish that the increased levels of the hormones were modulated in a time- and dose-dependent manner. Competing-risks Poisson regression methodologies were performed. The flash release process increased extraction of polysaccharides originating from grape berry cell walls, that is, polysaccharides rich in arabinose and galactose (PRAGs) and type II rhamnogalacturonan (RG-II), thus yielding enriched wines.

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Plasma cholecystokinin and pancreatic polypeptide secretion in response to bombesin, meal ingestion and modified sham feeding in lean and obese persons. In this paper, we describe the development of a culture-based biochip device for rapid detection of mycobacteria in environmental samples. All participants received 1h of manualized individual cognitive behavioral therapy on a weekly basis. Logistic regression and Cox proportional hazards were used to model the association between choice of glycoprotein IIlb/IIIa receptor antagonist and adverse events. pylori eradication in Irish patients but the importance of compliance cannot be underestimated. The radiation dose and tumor conformity index value were not significant prognostic indicators. Brain radionecrosis is a late complication rarely occurring in patients irradiated for UCNT. A variety of care professionals work in community settings to provide support to this population.

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These results suggest that increasing age results in a decrease in the elasticity of tendon-aponeurosis structures and an increase in their viscosity. Physiological behaviour of Hanseniaspora guilliermondii in aerobic glucose-limited continuous cultures. In agreement with other protective effects previously observed in the same animal models, the thiol N-acetylcysteine (NAC) totally prevented or significantly reduced the formation of carcinogen-DNA adducts in three experimental systems in rats. An intact B-box 2 domain is essential for the antiretroviral activity of TRIM5alpha. The infiltration formed soft tissue masses, with the thickened nerves shown to be penetrating the center of the masses on ultrasonography and magnetic resonance imaging. Cloning, promoter analysis and expression of the tumor necrosis factor receptor-associated factor 6 (TRAF6) in Japanese scallop (Mizuhopecten yessoensis). Minor impact that qualitative inquiry has on the development of nursing science. The protective effect of PrP(C) was further evident in that overexpression of mouse PrP(C) in SN56 cells transfected with Htt caused a decrease in both the number of cells with Htt granules and the number of apoptotic cells, whereas there was no effect of PrP(C) expression in non-neuronal NIH3T3 or CHO cells.

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Such zymogens can be considered as covalently bound enzyme-inhibitor complexes. Low patient health literacy has been associated with cost increases in medicine because it contributes to inadequate care. This makes the nanostructured ordered mesoporous Co3O4 a promising sensor material for detecting the alcohol gas. Retroillumination and slit-lamp-derived reflected-light photographs were taken on 23 consecutive eyes with posterior capsule opacification (PCO) in uncomplicated pseudophakia. Since the membership of voxels in boundary regions is intrinsically fuzzy, unsupervised fuzzy clustering methods turns out to be particularly suitable for handling the bone segmentation problem. In this study, novel methodology to prepare two types of decalin skeleton could be developed. Recent advances in applying such distance and orientation molecular rulers to biological systems are reviewed, and future prospects and challenges are discussed. Immunoperoxidase staining of intestinal sections from 20- and 40-week-old chickens revealed S. In multivariable models, BNP remained associated with increased risk of heart failure, whereas NT-proBNP remained associated with increased risk of cardiovascular mortality, heart failure, and stroke.

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The electrokinetic behaviour of normal erythrocytes is compared with that of trypsin-, N-bromosuccinimide-, and tosyl-treated erythrocytes. We report a 30-year-old researcher who became acutely ill with epigastric pain indicative of esophagitis or peptic ulcer disease. Between 1968 and 1982, 33 patients with a diagnosis of nonseminomatous tumors of the testis were referred to this center. At the end of the 1990s, controversy ensued: since reactive vaccination was fraught with so many problems, why not consider a strategy of preventive AC vaccination for high risk areas?. Sex differences in regulation of contact sensitivity reaction in mice. Skin tests using prepared Anisakis antigen and commercially available fish antigen were done. These equivalents must reflect typical average consumed amount of food and always within the group the content of the main nutrient has to be same/similar. In the short-term, S is both statistically and clinically superior to A.

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Urinary transferrin, high molecular weight proteinuria and the progression of renal disease. After 6 months, six animals were reevaluated and two were sacrificed, and the penises were excised. These results demonstrate the importance of Mbd3/NuRD for the development of pluripotent cells in vivo and for their ex vivo progression into embryonic stem cells, and highlight the differences between ES cells and the ICM cells from which they are derived. As a viable alternative to neutron diffraction, this paper introduces a new approach named the nuclear-weighted X-ray maximum entropy method (NXMEM) for reconstructing pseudo NDDs. Postoperative stereotactic radiosurgery to the resection cavity for large brain metastases: clinical outcomes, predictors of intracranial failure, and implications for optimal patient selection. The study included 94 women who underwent surgery for SUI, and the women were divided into two groups: 53 women had vaginal sling, and 41 women had Burch colposuspension. One hundred nine patients at the acute phase of a definite or possible infective endocarditis according to the Duke modified criteria and without neurologic manifestations according to the NIHSS were prospectively included. Aberrant DNA methylation of imprinted loci in sperm from oligospermic patients. At the present time there is virtually no data on mechanisms of immune regulation during human hantavirus infections. Further, our results suggest that non-steady-state data enhance the inferability of regulatory networks.

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Exposure estimates in epidemiological studies of Korean veterans of the Vietnam War. The observed photoinduced absorption is to an even-parity two-photon state that occurs immediately above the absorption edge. maltophilia was isolated from the blood cultures of all 3 patients. Ghrelin, a peptide produced in the stomach, which regulates appetite, food intake, and body composition, was studied in H. The findings suggest that the development of the brain in patients with remission resembles the normal development more than in patients with persistent tics. With the continued efforts of researchers in the laboratory and at the bedside, prevention of these catastrophic diseases may some day become a reality. The hair loss in 8 cancer patients aged between 18 and 60 years on chemotherapy was studied. Taken together, these findings indicate that the p53 pathway seems to play a crucial role in NB cell death by Noxa regulation in mitochondria, and inhibition of the induction of p53-downstream effectors may regulate drug resistance of NB cells.

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All the patients were operated on: 2--for an urgent indications because of the prosthesis suppuration and arrosive hemorrhage occurrence and 5--in elective order. Influence of EEG measurement montage on source localization error bounds due to head modeling errors caused by brain lesions. CTLs act as the effector arm of the cell-mediated immune system to kill undesirable cells. The effect of products of deep splitting of proteins in a culture medium on C. Defective catabolism of D-glucose and L-glutamine in mouse pancreatic islets maintained in culture after streptozotocin exposure. We prospectively evaluated thalidomide, an oral agent with antiangiogenic and immunomodulatory properties, in patients with recurrent ovarian cancer, comparing the drug to standard intravenous chemotherapy and treatment holiday in terms of both progression-free interval and quality of life. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. Imaging detailed glucose metabolism in the brain using MAP estimation in Positron Emission Tomography. A clinical, prospective, randomized, double-blind trial comparing skin whitening complex with hydroquinone vs. The purpose of the study was to determine the incidence of surgical site infection (SSI) in patients during hospitalization and after discharge from the hospital.

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Therefore, high infusion rates of pantoprazole should be avoided especially in heart failure patients. Chronic heat stress and respiratory alkalosis: occurrence and treatment in broiler chicks. Social competence should be well represented in the investigation of developmental functional impairment. Dose verification in carcinoma of uterine cervix patients undergoing 3D conformal radiotherapy with Farmer type ion chamber. Intervalence charge transfer luminescence: interplay between anomalous and 5d - 4f emissions in Yb-doped fluorite-type crystals. The CB1 antagonist, AM281, but not the CB2 antagonist, AM630, ablated URB597-mediated RGC neuroprotection. To prospectively and longitudinally examine how concussion affects gait balance control in adolescents during single- and dual-task walking.

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It is worth noting that although diabetes caused by INS gene mutations is rare, increasing evidence suggests that defects in the pathway of insulin biosynthesis may also be involved in the progression of more common types of diabetes. Linking traffic noise, noise annoyance and life satisfaction: a case study. Communicative abilities in children: an assessment through different phenomena and expressive means. Herpes simplex viruses type 1 and 2 (HSV-1 and HSV-2) are alpha herpes viruses. Insurance status was related to having a regular source of care, while uninsured children reporting most care in Mexico were less likely than uninsured children in the United States to have had a routine health care visit. Our spectroscopic and cytological results show that NY, either alone or counterstained with DA or MG, can be used for DNA cytochemistry and chromosome banding. Reconstructing the diversification of alpha-esterases: comparing the gene clusters of Drosophila buzzatii and D. We present an approach for inferring the complex causal relationships among genes from microarray experimental data based on a recurrent neuro-fuzzy method. CdSe quantum dots have been used as energy donors to activate meso-tetra (4-sulfonatophenyl) porphine dihydrochloride. Correlations were investigated between arrhythmias and the site of ventricular noncompaction, number of noncompacted segments, presence of fibrosis, and left ventricular dysfunction.

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We assessed the direct effects of local intra-arterial tumor necrosis factor-alpha (TNF-alpha), interleukin-6, and endotoxin on blood flow and endogenous tissue plasminogen activator (t-PA) release in vivo in humans. Parents reported demographic data, general health, and attention-deficit hyperactivity disorder (ADHD) symptoms. Our study demonstrates the wavelength range for optimal pulsed femtosecond laser excitation of THG from hemozoin crystals. This sensitive method was exploited to analyse factors contributing to signal strength in immunogold chromosome painting. There was a close correlation between antipyrine half-lives and induction of hepatic cytochrome P-450 dependent benzo(a)pyrene monooxygenase, 7-ethoxycoumarin O-deethylase and 7-ethoxyresorufin O-deethylase.

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When a broad range of spatial frequencies are present in the image, as in normal conditions of viewing, patients preferentially rely on coarse visual information contained in LSF. Carotid Intima Media Thickness as a Reflection of Generalized Atherosclerosis is Related to Body Mass Index in Ischemic Stroke Patients. The diagnosis of Autoimmune Hepatitis made by a Consultant Hepatologist is accurately communicated to and electronically recorded by primary care in the UK. Thyroglossal duct cysts were the most common congenital cervical cyst encountered. The biological response to this biomaterial on yarns and fabrics of the type used in cardiovascular surgery has been studied. A family outbreak of Escherichia coli O157 haemorrhagic colitis caused by pork meat salami. Internodes beyond the noroxin generic one containing the cell body bear only compact myelin. Prognosis in rectal cancer is closely related to mesorectal integrity, margin status, and adequate lymph node dissection. This review considers the methods for studying the systematics of Culicoides using both morphological and genetic techniques, with a view to understanding the factors limiting our current understanding of Culicoides biology and hence arbovirus epidemiology.

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The aim of this study was to evaluate the effects of the JAK inhibitor tofacitinib on MDSCs in a mouse model of rheumatoid arthritis. We also measured VEGF/VPF levels in serum specimens obtained from cancer patients with several types of cancers. The purpose of the appendix is to help police officers to perform and document cleocin iv cost tests confirming psychomotor impairment, as well as to provide the basis for saliva, urine and blood analysis. Primary care-managed patients with COPD at the highest risk of exacerbations can be identified by exploring medical history for the presence of prior exacerbations, greater COPD disease severity and co-occurrence of other medical conditions. Further research is needed to identify the antecedents of escalation to regular use and progression of regular use across substances and to delineate the cultural and environmental factors that affect substance-use progression. Megalin protein detected by immunohistochemistry was also observed in FS cells. The gallbladder and common duct problem as seen by the general practitioner and general surgeon. Theanine ingestion resulted in a substantial overall decrease in background alpha levels relative to placebo while subjects were actively performing this demanding attention task.

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The frequency of the tone generally followed the day-to-day shifts in the frequency of the associated spontaneous otoacoustic emission. Matched treatment sites were compared at energy densities of 20 and 24 J/cm(2) with and without the use of the cryogen spray in 18 patients. Knowledge of these areas is essential for accurate, timely diagnosis, which aids in optimizing patient outcomes. Brain Atlases are valuable tools that assist neurosurgeons during the planning of an intervention. This is run until a steady state is achieved for which a polymer distribution is predicted. A short synthesis of gabosine I (1) from delta-D-gluconolactone (3) in four steps, involving a one-pot TPAP oxidation-K2CO3-mediated intramolecular Horner-Wadsworth-Emmons (HWE) olefination as the key step, is described. The relative sizes of the bones of the hand and foot may provide helpful supplemental information on the relations between species, thus making the study of hand and foot bones in other primates and mammals worthwhile. Results of these experiments showed that the present HPLC method represents a valid alternative to currently available analytical techniques for assaying boronophenylalanine based on boron determination in terms of reproducibility, recovery, or sensitivity. However, the effects of genetic variation are not consistently seen and are sometimes conflicting.

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Surprisingly, we discovered that ERK1/2 are required for both the transcriptional and neuroprotective activity of MEF2C in cortical neurons stimulated by brain-derived neurotrophic biaxin penicillin factor. Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. The study of possibility to elevate antitumor activity and decrease of systemic toxic effects of cisplatin by its binding with deliganded albumin. Pertinent history, physical examination findings, and results of hematologic and biochemical testing were extracted from medical records. Our own poor results with percutaneous transluminal angioplasty for atherosclerotic lesions has prevented us from offering this option to patients with classic renal ostial lesions which are in essence an aortic disease that does not respond to this modality.

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Each lesion exhibited a different immunoprofile for CTR and GCR, pretreatment and during treatment. In many cases the approaches used in transgenic yeast may also be used for studies of the receptors in the native plant. Bacteria are equipped with complex cell surface structures, such as cell walls. Despite the small group of patients, our first results show laparoscopic total pericystectomy without opening the cyst cavity, in the treatment of hepatic hydatid cyst, as a good alternative to open surgery in selected patients. The stimulatory action of IL-1beta on PGE(2) production was totally abolished by NS-398, a how to take levaquin tablets specific inhibitor of cyclo-oxygenase-2 activity, as well as by the protein synthesis inhibitor cycloheximide, and the glucocorticoid dexamethasone. There has been a dominance of clinical and child-related papers in MCHC research, which may be a reflection of restricted outlooks of specialists in the area. Significance of Fas protein in squamous cell carcinoma of the larynx. Side-room tests to screen for microalbuminuria in diabetes mellitus. The elaboration of the Framework for Responsible Sharing of Genomic and Health-Related Data serves as an illustration of this process. The carbohydrate carcinoma antigens CA 125, DF3 and Sialyl Lewis(a) were detectable in some of the malignant and normal renal cells.

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Sedation with midazolam for voiding cystourethrography in children: a randomised double-blind study. Following blood collection, the capillary is placed into a secondary labeled container suitable for centrifugation and plasma is generated. Nasal symptoms and clinical findings in adult patients treated for unilateral cleft lip and palate. Patterns of gastrointestinal parasitism among five sympatric prairie carnivores: are males reservoirs?. The use of an cleocin brand name individualized prophylactic regimen may also improve cost-effectiveness and make the use of this treatment modality more feasible. Family violence affects a significant proportion of the US population either as direct victims or as witnesses of abuse. Here, we summarize what is known about hypothalamic fatty acid metabolism and feeding control and provide future directions for research. As a result, the range of accessible morphologies increases with the generation, from a dense-shell model in low generation to a model intermediate between a dense shell and a dense core in high generation. Multivariate linear regression models were constructed to assess the relationship between f/VT and other pulmonary-related variables.

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The controlled effect sizes for CBT were substantial (range 1.7-2.7), which suggests it may be a particularly efficient way of managing therapeutic exposure to feared situations in panic disorder with agoraphobia. To study the efficacy and safety of tacrolimus in primary membranous nephropathy. Neighbourhood safety and area deprivation modify the associations between parkland and psychological distress in Sydney, Australia. Although there was no correlation between visual degradation and AR, CT, CCC, LLT, or the presence of striae or corneal edema, visual degradation correlated positively with the polygonal reflex, which was observed following warm compress application. Apelin is novel adipokine acting on APJ receptor, regulated by insulin and tumor necrosis factor-alpha (TNF-alpha). To understand how gene expression is controlled on a genome-wide scale, methods for assaying transcription factor binding sites are required. The influence of dislocation on functional outcomes of primary total hip arthroplasty is unclear.

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The value of lgKd (24-2.6) demonstrates the hydrophobicity of the rifabutin molecule. After the IDM containing chitosan/alginate multilayer film is obtained on the surface of Cu/LDPE composite intrauterine device, its release behavior of both IDM and cupric ion has been studied in vitro. The present results indicate TSSA remained effective in classifying subjects into subgroups with greater risk of morbidity and mortality related to cardiovascular disease after ten additional years. Pelvic osteotomies have the advantage of a high potential of correction without the biomechanic disadvantages which are associated with intertrochanteric varus osteotomies. The natural history of the univentricular physiology is determined primarily by the presence (severity) or absence of obstruction to pulmonary blood flow and secondarily by the single ventricular cardiomyopathy that develops in response to chronic volume overload. Participants were selected by probability sampling and were interviewed by telephone.

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The effects of an experimental antiepileptic drug R 57720 (Janssen Pharmaceutica) on metrazol-induced seizures were studied in rats aged 7, 12, 18, 25 and 90 days. Correlation between hindfoot joint three-dimensional kinematics and the changes of the medial arch angle in stage II posterior tibial tendon dysfunction flatfoot. The mechanism of cimetidine-induced prolactin (PRL) release was studied. We demonstrated that cell death induced by ACTX-8 was concentration- and time-dependent. A comparison was made between patients referred to our tumor center before surgery (n 195), after surgery (n 102), and not referred for the primary tumor (n 78).

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