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Metrosept (Metronidazole)

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Metrosept is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

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Also known as: Metronidazole


Metrosept (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metrosept is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the pres- ence of the trichomonad be reconfirmed by appro- priate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.


In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Metrosept overdose, Metrosept infusion should be discontinued. Patients should be treated symptomatically.


Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Metrosept are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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Alveolar-derived exhaled nitric oxide is reduced in obstructive sleep apnea syndrome. The level of cyclic GMP was found to increase significantly in the early stage of acute hepatitis, in the decompensated stage of liver cirrhosis, and in malignant diseases. Genetic analysis of the PKC1/STT1 protein kinase C gene and its interactions with STT4, encoding an upstream phosphatidylinositol 4-kinase, and BCK1, encoding a downstream protein kinase, reveal that they form part of a single pathway. Methods were evaulated with respect to the time required to reduce the population to a target level, the number of animals treated and/or culled and the risk of extinction. The authors have studied changes of glucosyl-, galactosyl- and sialyl-transferase activities in the sera of women during pregnancy and the early post-partum period, and in neonates from birth to 1 yr of age. A dosing of 0.75 mg/kg/day or 1.5 mg/kg/day is as effective as 50 mg/day or 100 mg/day in adults. High-resolution deletion analysis is a useful tool for assessing the risk of Wilms tumour in neonates with aniridia. Susceptibility to pulmonary hypertension in inbred strains of mice exposed to cigarette smoke.

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Effectiveness of two intracanal dressings in adult Portuguese patients: a qPCR and anaerobic culture assessment. Physicochemical forms of (90)Sr and (137)Cs in components of Glyboke Lake ecosystem in the Chornobyl exclusion zone. Homologous recombination in fission yeast: absence of crossover interference and synaptonemal complex. Regions with apparently increasing risk include the jaw, wrists, hips, and knees. On the basis of this new method, both proper identification of areas with critically reduced brain tissue perfusion and classification between brain perfusion defects and ultrasound stripe artifacts are made possible. Comparison of two multistage cluster random sample surveys taking into account the marked increase in population in the Gambia, west Africa. Subsequent functional analyses revealed that the transcriptional activity, subcellular localization and DNA binding affinity of some mutant GATA4 proteins were significantly altered. Gene Expression Data for DLBCL Cancer Survival Prediction with A Combination of Machine Learning Technologies. More information on them and on the complex relationships between parasites, vectors and human beings is required, and inter-territorial co-operation is essential in obtaining this information and in planning.

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Radiation-induced gastrointestinal stromal sarcoma of the esophagus. This paper is focused on statistical modelling, prediction and adaptive adjustment of patient recruitment in multicentre clinical trials. In this paper, the biology of the infective stage larvae of the nematodes responsible for lymphatic filariasis and the approaches used to study their development are reviewed. ZD1839 activated caspase-3 and the inhibited Bcl-2 in human leukemic U937 cells through the downregulation of the ERK and PI3K/Akt pathways. Direct action of the nodal-related signal cyclops in induction of sonic hedgehog in the ventral midline of the CNS. We aimed to assess whether provision of a combination of IPV prevention and HIV services would reduce IPV and HIV incidence in individuals enrolled in the Rakai Community Cohort Study (RCCS), Rakai, Uganda. The intrinsic fluorescence decay requires at least four exponentials at both pHs. The combination of ultrasound-guided SGB and simultaneous pharmacological and occupational therapy showed encouraging treatment results under conditions of this pilot case series.

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Rearing Culicoides variipennis sonorensis (Diptera: Ceratopogonidae) on agar and nematodes. It represents an important tool for the assessment of incontinent women in clinical trials. Alternative oncological treatment: psychological support for cancer patients - means for a better quality of life or better survival. In patients who are admitted to the emergency department with the loss of consciousness and stroke, inadequacy of anamnesis and carotid artery involvement of aortic dissection should be kept in mind. In-depth interviews were conducted with 19 HIV-positive people receiving ART through a public hospital in KwaZulu-Natal. This study shows that the risk of eczema or recurrent wheeze at 1 year of age does not differ between infants with different vaccination status at the age of 6 months.

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Functional recovery and axonal growth following spinal cord transection is accelerated by sustained L-DOPA administration. Cyclic AMP induces terminal deoxynucleotidyl transferase in immature B cell leukemia lines. New technology has enabled the increasing use of radiosurgery to ablate spinal lesions. Clinical Evidence (BMJ Group) sections and related search strategies regarding MI were used to identify multiple SRs published between 1997 and 2007. The sensitivity to inhibition of vasoconstriction in pithed rats to the different agonists increased in the order cirazoline much less than St 587 less than Sgd 101/75 less than B-HT 920. Influence factors for successful corneal donation among Chinese adults: data from Nanjing between 2001 and 2012. Chromatographic fingerprint analysis of Cephalotaxus sinensis from various sources by high-performance liquid chromatography-diodearray detection-electrospray ionization-tandem mass spectrometry.

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Technology insight: can autoantibody profiling improve clinical practice?. However, the questionnaire results give no direct explanation for the differences between the countries except the variation in using personal care products. Neuropathy is the main adverse effect, but appears to be cumulative dose-dependent, thus allowing long-term remission before drug suspension. Static perimetry may be a valuable, complementary method in addition to examinations used so far in the diagnosis of multiple sclerosis. Six cases of choriocarcinoma, 17 of vesicular mole, 20 normal pregnant females in the first trimester of pregnancy, and 20 normal nonpregnant women wih previous normal obstetrical history were evaluated quantitatively for cell-mediated immunity by response to 2:4 dinitrocholorobenzene and recall antigens. Malaria is an important cause of mortality and morbidity in sub-Saharan Africa. A total of 882 treatment-seeking obese patients with BED were administered structured interviews (Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition Axis I Disorders) and completed self-report questionnaires. After aortic dissection, an 8-mm graft was passed through a retroperitoneal tunnel.

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SEEDO 2007 Consensus for the evaluation of overweight and obesity and the establishment of therapeutic intervention criteria. We quantified virus-derived small RNAs (vRNAs) generated by mosquito (U4.4) cells and interferon-deficient (Vero) and interferon-competent (HuH-7) mammalian cells infected with a single isolate of mosquito-borne dengue virus. The mechanical stiffness and swelling ratio of the hydrogels were tunable with the molecular weight of the HA and the concentration/composition of the precursor solution. Private speech and strategy-use patterns: bidirectional comparisons of children with and without mathematical difficulties in a developmental perspective. These results indicate that both VPg and the host eIF4E are involved in the host tropism of BaYMV and WYMV at the replication level.

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