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Metroderme (Metronidazole)
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Metroderme

Metroderme is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

Other names for this medication:
Amobin, Anegyn, Arilin, Corsagyl, Dequazol, Efloran, Fladex, Flagystatine, Flazol, Flegyl, Geloderm, Ginerella, Gynoplix, Gynotran, Imizine, Klion, Medamet, Metco, Metral, Metrocev, Metrocream, Metrodal, Metroderme, Metrogel, Metronidazol, Metronidazole, Metrozol, Minegyl, Nizole, Novazole, Otrozol, Perilox, Repligen, Rhodogil, Robaz, Rodogyl, Rosazol, Stomorgyl, Trichozole, Vagizol, Venogyl

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Also known as: Metronidazole

Description

Metroderme (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metroderme is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

In the Female. One-day treatment – two grams of Metroderme, given either as a single dose or in two divided doses of one gram each, given in the same day. Seven-day course of treatment – 250 mg three times daily for seven consecutive days. There is some indication from controlled comparative studies that cure rates as determined by vaginal smears and signs and symptoms, may be higher after a seven-day course of treatment than after a one-day treatment regimen.

The dosage regimen should be individualized. Single-dose treatment can assure compliance, especially if administered under supervision, in those patients who cannot be relied on to continue the seven-day regimen. A seven-day course of treatment may minimize reinfection by protecting the patient long enough for the sexual contacts to obtain appropriate treatment. Further, some patients may tolerate one treatment regimen better than the other.

Pregnant patients should not be treated during the first trimester In pregnant patients for whom alternative treatment has been inadequate, the one-day course of therapy should not be used, as it results in higher serum levels which can reach the fetal circulation.

When repeat courses of the drug are required, it is recommended that an interval of four to six weeks elapse between courses and that the presence of the trichomonad be reconfirmed by appropriate laboratory measures. Total and differential leukocyte counts should be made before and after re-treatment.

Overdose

In cases of overdose in adults, the clinical symptoms are usually limited to nausea, vomiting, ataxia and slight disorientation. In a preterm newborn, no clinical or biological sign of toxicity developed.

There is no specific treatment for Metroderme overdose, Metroderme infusion should be discontinued. Patients should be treated symptomatically.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Metroderme are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Metronidazole should be used with caution in patients with active disease of the Central Nervous System. The treatment should be withdrawn in case of ataxia, dizziness, or confusion. The risk of aggravation of the neurological state should be considered in patients suffering from severe central and peripheral neurological diseases, fixed or progressive paraesthesia and epilepsy. Caution is required in patients with active disease of the central nervous system except for brain abscess.

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Although high and low temperature stresses impose different metabolic and physical challenges, acquired tolerance appears to involve general as well as stress-specific components. Protective immunity of rTs87 can be enhanced by adjuvant CFA or IFA, IMS1312, ISA720, Quil-A and Al(OH)3, and better effect is observed with the latter 3 adjuvants. bulgaricus ATCC 11842 were treated with enterolysin A, and liberated amino acids were derivatized for N and C terminals and analysed using thin layer chromatography on silica gel with isopropanol as solvent. We report a case of a 70-year-old man with previous history of treated stage III adenocarcinoma of the rectum 26 months ago. The mean frequency of the sampled Doppler signal, obtained with the autocorrelation function, reflects the mean velocity of the scatterers moving through the sample volume. Structural and mechanistic peculiarities between the different tRNA/aaRS couples, suggest that aminoacylation systems are unrelated.

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ExbB and TonB interact through their respective transmembrane domains. People living in and travellers going into such areas might be more exposed to TBE virus than estimated, based on the current epidemiological maps. In this perspective it has been suggested that the redox balance and the oxidative stress (OS) may represent interesting and under-explored candidates as promoting factors in HPV-initiated carcinogenesis. One type of accessory cell has dark cytoplasm, few microtubules, and contacts the sensory cell directly, whereas a second type has pale cytoplasm, many microtubules, and forms an outer layer not directly in contact with the sensory cell. To compare cardiovascular disease (CVD) risk factor levels of men and women in a local workforce with measures of socioeconomic (SES) status.

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The functional significance of the serotoninergic input to the suprachiasmatic nucleus in ontogenesis is discussed. Furthermore, if source information is encoded explicitly, the frontal cortex does not appear to be necessary for its retrieval. Right Ventricle Extraction by Low level and Model-based algorithm. The relationship between age-related glycation and a fluorescent product attributable to the advanced Maillard reaction was investigated in the aortas of rats between 4 and 120 weeks of age. Insulin sensitivity has been implicated in the variation of fat accumulation in early gestation by as-yet-unknown mechanisms. Ocular osseous choristoma, a rare idiopathic benign deposit of bone, is typically a static epibulbar lesion that occurs sporadically in the supertemporal quadrant of an otherwise normal eye. A broad, therapy-induced antibody response was uncovered, which primarily targeted intracellular proteins that function in growth, transcription/translation, metabolism, and homeostasis.

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Em was determined with glass microelectrodes and isometric force was simultaneously measured with a copper-berylium strain gauge. Plasma level of TNF-alpha or sTNFR was of little value in predicting the occurrence of early septic shock in ASP. The result showed that TCDD does not show any effect on the expression of steroidogenic acute regulatory protein mRNA in both strains. Stoichiometric results indicated formation of two hydroxyl radicals to degrade 1 mol of muconic acid. Our goal was to investigate the kinetics of serum IgG antibodies against Bartonella spp. However, neurotensin-induced hypothermia occurring after injection into the preoptic area does not appear to involve dopamine systems. These preliminary results demonstrate the safety and effectiveness of VAWC for the treatment of deep alloplastic graft infections. A single technology platform was introduced, as was providing round-the-clock patient placement by critical care nurses, and adding medical directors.

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PCI increased only by 0.36 more procedures per month (approximately four per year), whereas more evident was the concurrent reduction of isolated CABG (4.15 fewer per month, that is fifty fewer per year). Pulmonary eosinophilia is one of the most consistent hallmarks of asthma. To date, these findings have been confirmed operatively in five of the eight patients. In addition, reactive oxygen species such as hydrogen peroxide and superoxide that can mediate oxidative pathology also mediate changes in channel function via alterations of thiol groups. Higher amounts of ascorbic acid and GSH supported the higher antioxidant ability. Human diseases have to be studied in parallel with their animal models to ensure that the model mimic at least a few original mechanisms, on which new therapeutics may be tested. Surgical monitoring using palpation of vessels and pulse oximetry of the great toe were initially proposed as simple and relatively inexpensive modalities for routine surgical monitoring. The form of administration of the vaginal ring, seems to be more acceptable than oestriol pessaries. The perceptual coding method revealed that pitch range, length of utterance, and total amount of sound significantly discriminated sarcastic from non-sarcastic utterances. Our study showed a significant increase of all forms of AGEs and corresponding changes in the activity of cathepsin B, both in plasma and neutrophils.

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Novel broccoli 1-aminocyclopropane-1-carboxylate oxidase gene (Bo-ACO3) associated with the late stage of postharvest floret senescence. Each of these lines has the structure of a random walk of various lengths on an fcc defect lattice. Qualitative RT-PCR was used to investigate the expression profile of different P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, and P2Y6), and in situ hybridization studies were performed to show their cellular localization within the retina. Previous tools and studies illustrate the opportunities of data mining across multiple tiers of neuroscience and genetic information. The cycle is fully reversed by the addition of triethylamine (TEA). Patients with below and above median baseline for one parameter, for example, IPSS had rather similar values for the other two parameters, for example, Q(max) and BOOI. Palaeobiological ramifications of these findings include the potential to deduce reproductive lifespan, fecundity and reproductive population sizes in non-avian dinosaurs, as well as aid in the identification of secondary sexual characteristics. The latter may correspond to a major reduction in African equatorial forests around the Last Glacial Maximum. Comparison of skin resistance between biological active points of left and right hands with various contact pressures.

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Specific binding sites for inositol 1,3,4,5-tetrakisphosphate are located predominantly in the plasma membranes of human platelets. Exposure of macrophages to lipopolysaccharide induced the mRNA of interferon-gamma, but the induction was significantly blocked by propofol. Follistatin decreases activin-stimulated FSH secretion with no effect on GnRH-stimulated FSH secretion in prepubertal male monkeys. This is the first example where the Mitsunobu approach has been utilized for the construction of S-amino acid based seven- and eight-membered ring systems. We investigated the effect of 3 affinity-purified anti-beta2GPI IgG preparations from patients with Hughes syndrome on fibrin polymerization and fibrinolysis of normal plasma, measured by comparing the optical densities of assay mixtures in the presence of the autoantibodies or normal IgG. ALA appears to improve neuropathic symptoms and deficits when administered via parenteral supplementation over a 3-week period. NF-kappaB activation is an early event and may play an important role in proinflammatory gene over-expression in rat gastric mucosa during WIR stress. In this multicenter case series, we aimed to characterize the contemporary role of minimally invasive surgery (MIS) in pediatric trauma.

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Based on these statistical inferences it was concluded that Lomax(R) is bioequivalent to Maxaquin(R). and Enterocytozoon bieneusi in dairy cattle, beef cattle and water buffaloes in China. These results subsequently led us to explore the potential of truncated recombinant G as a diagnostic antigen in ELISA. Imaging of fluorescent dyes localizing in the plasma membrane, mitochondria, or nucleus confirmed that evanescent wave radiation excited only dyes in and near the plasma membrane. Systematic screening of breast cancer after fifty: an arbitrary limit?.

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This study shows for the first time that TrxR may be an important antioxidant defense mechanism in PBMC that is compromised during the periparturient period. Knutson Distinguished Service Award in Dental Public Health--1998 recipient Myron Allukian, Jr. The small and medium business sector is a major provider of private sector employment in Australia, yet we have little information about the preparedness of this sector for pandemic influenza. alginolyticus, a 30-fold increase in volumetric productivity of soluble xanthan lyase was achieved by heterologous production in E. Morphine inhibits small intestinal transit in mice, although few mu-opioid receptors are present in the ileum. By pretreating with cycloheximide prior to irradiation, we observed a decrease in the protein half-life, from 3.5 h to 53 min, suggesting that a decrease in protein half-life may cause the lower levels of BRCA1 after irradiation. This article examines the occurrence of MTS-induced hypertrichosis in females. Electrophysiological study of the corticonuclear projection in the cat cerebellum. No increased uptake was seen in the heart outside the infarct area.

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