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Metrocream (Metronidazole)
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Metrocream

Flagyl is an oral antiprotozoal and antibacterial. It is thought to work by entering the bacterial cell, acting on some components of the cell, and destroying the bacteria. Treating certain infections caused by bacteria or amoebas. It may also be used for other conditions as determined by your doctor.

Other names for this medication:
Arilin, Asuzol, Biatron, Etron, Fladystin, Flagemed, Flagenase, Geloderm, Mecozol, Metco, Metrazol, Metrocream, Metrolyl, Metrozole, Metsina, Otrozol, Patryl, Rovamet, Rozacrme, Servizol, Suanatem, Supplin, Trichazole, Tricozyl, Vagilen

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Rulide, Myambutol, Flagyl, Amoxil, Avelox, Floxin, Vantin, Cleocin

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Also known as: Metronidazole

Description

Metrocream (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Metrocream is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.

Dosage

Metrocream 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Metrocream and 250 on the other side; bottles of 50, 100, and 2,500. Metrocream 500-mg tablets are oblong, blue, film coated, with Metrocream debossed on one side and 500 on the other side; bottles of 50, 100, and 500.

Overdose

Single oral doses of Metrocream, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Metrocream has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Metrocream overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.

Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Metrocream are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Metronidazole is mainly metabolised by hepatic oxidation. Substantial impairment of Metronidazole clearance may occur in the presence of advanced hepatic insufficiency. The risk/benefit ratio of using Metronidazole to treat trichomoniasis in such patients should be carefully considered. Plasma levels of Metronidazole should be closely monitored.

Cases of severe hepatotoxicity/acute hepatic failure, including cases with a fatal outcome with very rapid onset after treatment initiation in patients with Cockayne syndrome have been reported with products containing metronidazole for systemic use. In this population, metronidazole should therefore be used after careful benefit-risk assessment and only if no alternative treatment is available. Liver function tests must be performed just prior to the start of therapy, throughout and after end of treatment until liver function is within normal ranges, or until the baseline values are reached. If the liver function tests become markedly elevated during treatment, the drug should be discontinued.

Patients with Cockayne syndrome should be advised to immediately report any symptoms of potential liver injury to their physician and stop taking metronidazole.

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A total of 56 participants were randomized and 40 participants were included in the analyses. New bone trabeculae were forming in the fibrous tissue of the distraction gap containing all stages of intramembranous bone formation. Presented in this Communication are the structure, physicochemical properties, and catalytic promiscuity of a new dinuclear CuII(mu-OH)CuII complex containing a novel N,O-donor symmetric dinucleating ligand. Experimentally, the amplitude tends to be reduced with anticorrelated stimuli and a spread of phase differences is observed, although phase differences near pi are the most common. Transcranial magnetic stimulation and peripheral nerve excitability studies were undertaken in 5 stroke patients with upper limb spasticity before (T1) and 6 weeks after (T2) botulinum injection. We compared the ATP concentration and mucosal permeability in Group P-5 with grafts preserved in 1 atm oxygenated-PFC/UW solution (Group P-1) and simple cold storage in UW solution (Group C). However, within this region there are approximately 20 kb sub-domains of high intergenic transcription that occurs outside of S phase. Preferential in-vitro growth and expansion of leukemic T lymphoblasts. Enhancement of fibroblast growth factor receptor 2 (FGFR2) gene expression was detected by microarray using 3 distinct probes. Increasing stroke incidence and prevalence of risk factors in a low-income Chinese population.

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32 feet in 27 adults, seen at The Johns Hopkins Hospital Foot and Ankle Clinic from 1993-1998, with the diagnosis of tarsal coalition were retrospectively reviewed. We included randomized controlled trials of nonsurgical treatments for abnormal uterine bleeding presumed secondary to endometrial dysfunction and abnormal uterine bleeding presumed secondary to ovulatory dysfunction. The brain and testicular antioxidants, SOD, GST, and GSH, decreased by Cd alone, were restored by beta-carotene cotreatment. An additional challenge is the difficulty in differentiating between the fetus that is constitutionally small and fulfilling its growth potential and the small fetus that is not fulfilling its growth potential because of an underlying pathologic condition. We observed the nutrition status, infective complications and mortality between the two groups for 21 days. Differential expression was confirmed for the following genes: keratin K5, cystatin S, serum amyloid A, the human homologue of yeast ribosomal S28 and the p32 subunit of human pre-mRNA splicing factor SF2. In study 2, after the creation of a full-thickness cartilage defect and resection of the synovium, the synovium of the GFP rats was transplanted into the unilateral knee (cartilage defect with transpl.synovium group). Early surgery reduces mortality in patients with infective endocarditis: insight from a meta-analysis.

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Platelet monoamine oxidase activity in neuroleptic-naive schizophrenic patients: lack of influence of chronic perphenazine treatment. Organ growth only occurred in the small intestine and liver in snakes fed on a high protein diet. If the SIRS and dysfunction of two or more organ were defined in animals after ROSC, the signs, biochemical markers and nonspecific pathological changes could be accepted to evaluate the PR-MODS. Remarkable synteny conservation of melanocortin receptors in chicken, human, and other vertebrates. Evading this defense mechanism is one of the most difficult requirements for transplant success, but it leads to a series of consequences, mainly related to infection. Simultaneous determination of multi-component vitamins by CPA spectroscopic computing analysis.

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was evaluated by comparing MICs, minimal fungicidal concentrations (MFCs), and epidemiological cutoffs (ECOFFs). Compared to linear elements, the cubic Hermite solution was found to have a much smaller RMS error. We discuss inhibitors against rRNA that may be designed according to nucleotide sequence and higher order structure. Analysis of part of the chicken Rfp-Y region reveals two novel lectin genes, the first complete genomic sequence of a class I alpha-chain gene, a truncated class II beta-chain gene, and a large CR1 repeat. Synthesis of pyrroles by click reaction: silver-catalyzed cycloaddition of terminal alkynes with isocyanides. Characteristics of bovine luteal cells in culture: morphology, proliferation and progesterone secretion in different media and effects of LH, dibutyryl cyclic AMP, antioxidants and insulin. Palatopharyngeal muscle specimens were taken from 51 patients with obstructive sleep apnea hypopnea syndrome (OSAHS) who underwent uvulopalatopharyngoplasty (UPPP) resection.

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Results from randomized controlled trials (RCT) concerning cardiac and renal effect of remote ischemic preconditioning(RIPC) in patients with stable coronary artery disease(CAD) are inconsistent. The molecular mechanisms by which pathogen molecules activate NBS-LRR proteins are poorly understood. The World Health Organization analgesic ladder and the Analgesic Quantification Algorithm are used to evaluate analgesic use. Our data indicating differences in the expression and sensitivity of the CYP2B isoenzymes in cultured rat brain cells will help in identifying and distinguishing xenobiotic metabolizing capability of these cells and understanding the vulnerability of the specific cell types toward neurotoxins. Short- and long-term results of angioplasty for multiple coronary stenoses. Therapies that aim to restore the balance between CD205 and CD80/CD86 may help to re-establish tolerance in patients with ITP. Persistence of virus without clinical consequences was observed when the supply of breast milk anti-JHMV antibodies was terminated 5 days before infection. Anatomical, textured, and cohesive gel implants were used, with a mean implant size of 235 cc (range, 180 to 300 cc).

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Mesotocin and maternal care of chicks in native Thai hens (Gallus domesticus). Half of each group received focalized hippocampal irradiation to inhibit neurogenesis prior to wheel running. Beta event-related desynchronization as an index of individual differences in processing human facial expression: further investigations of autistic traits in typically developing adults. Mean nitrogen removal was 520 lbs acre(-1) year(-1) (58 g m(-2) year(-1)). Subsequently, the patient was referred for brachytherapy with radical intent. The connective tissue graft procedure is an effective method to achieve root coverage. MYB4-OX switchgrass is an excellent model system for understanding recalcitrance, and provides new germplasm for developing switchgrass cultivars as biomass feedstocks for biofuel production.

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We describe experiments using hypothermia in the rabbit retina in vitro that show a correlation between hypothermia-induced reductions in energy usage and neuroprotection. Absorption of 32P by plants under different conditions of temperature and illumination. Substantial past experience validates these generally qualitative notions. Endotoxin causes gastric dysfunction and upregulates stress-inducible phosphoproteins within minutes after LPS. Before and after 5 x 5 Gy of RT, dynamic contrast-enhanced -magnetic resonance imaging was performed and endothelial permeability surface product (PS), plasma flow (F), and blood volume (V) were modelled. Prior ultrasound scans done at various post-transplant periods had all been normal. The author proposed to increase female managers intentionally, so that the sense of sexual difference would be diminished and proper evolution of the society would be achieved. Ependymoma is a slowly growing tumor in children and young adults originating from the wall of the ventricles or from the spinal canal that is composed of neoplastic ependymal cells. Selected topics in cancer biology can be used to motivate K-12 teachers and students to learn more about basic normal biology while simultaneously learning about cancer. To investigate this inflammation, we measured the eosinophil cationic protein (ECP), regulated on activation normal T-cell expressed and secreted (RANTES) and eotaxin levels in nasopharyngeal secretions (NPS).

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The probability of finding GLUT1D in the classical idiopathic generalized epilepsies is very low. Laser treatment is effective for diabetic macular oedema and proliferative diabetic retinopathy. The conventional-type fuel cell containing Gram-negative bacteria, Proteus vulgaris, was investigated as a model system. In particular problems related to lack of motivation, uncertainty about what was expected of them, difficulty in expressing personal thoughts and feelings and the subsequent anxiety that this created. The validation method presented here is an important step toward more generic simulations of biomechanically plausible tissue deformations and quantification of tissue motion recovery using nonrigid image registration. Developing an ICF core set for these patients might prove useful.

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To study the associations of patient-related and perceived healthcare-related factors with the control of blood pressure. Crystal structures of two functionally different thioredoxins in spinach chloroplasts. We have demonstrated, in animals and humans, that fenretinide induces a rapid reduction of retinol plasma concentration, that its blood levels remain constant during administration for as long as 5 years, and that the drug is able to accumulate in the human breast. From genetics of inflammatory bowel disease towards mechanistic insights. Most general practice attendees expressed intentions to seek health care urgently for most symptoms suggestive of TIA, with highest levels of urgency observed in high stroke-risk scenarios. By varying the reaction conditions, we enhanced the growth of PHB on solid surfaces and analyzed the resulting structures by fluorescence microscopy, atomic force microscopy (AFM), attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, and gel permeation chromatography (GPC). A resected case of thoracic esophageal cancer in which pCR was obtained using low-dose of nedaplatin (CDGP)/5-FU and radiotherapy. Differential screening of a cDNA library constructed from cold acclimated crown tissue of winter wheat identified three novel CA-associated cDNA clones. Immunocytochemistry using confocal microscopy showed moesin to zithromax antibiotic uses be primarily localized on the inner aspect of the plasma membrane and around secretory granules. Middle ferritin genes from the icefish Chionodraco rastrospinosus: comparative analysis and evolution of fish ferritins.

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Within medical education, there is a discrepancy between the achievement level of White students and that of their ethnic minority peers. The most dramatic finding from FLP chemistry was the discovery that FLPs can activate H2, thus countering the long-existing dogma that metals are required for such activation. We conclude that hyperdynamic sepsis increases blood flow to heart, gut and kidney and that NE further increases cardiac output, blood pressure, myocardial performance, and urine output and creatinine clearance while maintaining regional blood flow. In order to investigate the involvement of pituitary beta-endorphin in electroacupuncture analgesia (EAA), the effects of hypophysectomy, dexamethasone (Dex) and adrenalectomy on the analgesia and the increase in plasma corticosterone (Cort) and ACTH levels produced by electroacupuncture (EA) were studied in male SD rats. Direct evidence that IE2 molecules are associated with viral DNA early after HCMV infection was obtained using fluorescence in situ hybridization.

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Natural products of microbial origin continue to be an important source of pharmaceuticals and agrochemicals exhibiting potent activities and often novel modes of action. Prevalence of Borrelia on tick collected in Yamanashi Prefecture. 8-Chloro-adenosine(8-Cl-Ado) is an anti-tumor drug,which has been investigated and developed recently in China. Direct detection of vanB2 using the Roche LightCycler vanA/B detection assay to indicate vancomycin-resistant enterococcal carriage--sensitive but not specific. By contrast, the loss of CD19 resulted in modest B-cell proliferation against anti-RP105 stimulation as well as LPS stimulation. These mechanistic similarities may be the result of convergent evolution, but in at least one case-hedgehog protein autoprocessing-there is definitely a close evolutionary relationship to protein splicing. Metformin improves cardiac function in isolated streptozotocin-diabetic rat hearts. In an effort to determine whether this nitration is directed toward a particular tyrosine residue or randomly distributed among all three tyrosine residues, the goal of this study was to determine whether a singly nitrated molecule was always nitrated at a particular tyrosine residue or whether the initial nitration event was randomly distributed among all three tyrosine residues. Porcine antithrombin III (AT III) has been identified to be a sperm-motility-stimulating protein and a chemoattractant for boar sperm. The capacity of the crown ion exchanger was 2.3 meq/g dry resin.

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Characteristics of Angora rabbit fiber using optical fiber diameter analyzer. This finding may have an impact on decision making for surgical resection of metastatic disease. Self-assembly of amphiphilic plasmonic micelle-like nanoparticles in selective solvents. Extracellular effects and compensatory changes in brain physiology complicate assessment of neuronal death in vivo as the result of seizures. The spvA gene product negatively regulated spvR expression in a dose-dependent manner, indicating that SpvA provides a negative feedback mechanism for this operon. Value of information analyses may have a meaningful role in research topic prioritization for comparative effectiveness research in the United States, particularly when large differences in VOI across topic areas are identified. p27(Kip1) expression effectively retards proliferation, but it is not sufficient to induce apoptosis in K562 cells. The effect will be more pronounced in species with relatively short map lengths.

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A gastric fibrolipoma presenting as acute gastrointestinal hemorrhage. To identify the domain(s) important for RNA binding and oligomerization of the protein, a number of deletions were made in regions of the gene that code for either the amino or carboxy terminus of the protein. The objective of this study was to investigate the effects of capillary network anastomoses and tortuosity on oxygen transport in skeletal muscle, as well as the importance of muscle fibers in determining the arrangement of parallel capillaries. Correct diagnosis was made by aortography or at exploratory thoracotomy. The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions.

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The use of norbornene units to induce the formation of beta-sheet and beta-turn type structures in levaquin dosing esrd peptides is discussed. Enhanced timing abilities in percussionists generalize to rhythms without a musical beat. The clinical performance of porcine bioprostheses for valve replacement has been evaluated for over three decades by actuarial analysis as the standard for reporting time-related results. The MBD1-CAF-1 p150 interaction requires the methyl-CpG binding domain of MBD1, and the association occurs in the C terminus of CAF-1 p150. In MBC, longer epirubicin-based regimens are better in terms of response duration and TTP. Neurological complications of cancer are some of the most feared manifestations of malignant disease. Many studies have investigated the effect of psychosocial factors on bereavement outcome but biological factors have not received much attention, hence the focus of this paper. Spraying for longer than the optimal tau(s) does not critically impair cooling selectivity. Atrial natriuretic factor in normal newborn infants and its effects on kidney function in anoxic syndrome and respiratory distress.

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