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Macrosil (Roxithromycin)
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Macrosil

Macrosil is a semi-synthetic macrolide antibiotic. It is a white crystalline powder. Macrosil is very slightly soluble in water, freely soluble in acetone, in alcohol and in methylene chloride. It is slightly soluble in dilute hydrochloric acid.

Other names for this medication:
Acevor, Asmetic, Assoral, Biaxsig, Bicofen, Biostatik, Cadithro, Claramid, Crolix, Dorolid, Elrox, Erybros, Floxid, Infectoroxit, Macrolid, Makrodex, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Redotrin, Remora, Ritosin, Rokithrid, Roksimin, Roksolit, Rolexit, Rolicyn, Rolid, Rossitrol, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin

Description

Generic Macrosil belongs to macrolides group of antibiotics which are prescribed for treating serious bacterial infections such as acute pharyngitis (sore throat and discomfort when swallowing), tonsillitis, sinusitis, acute bronchitis (infection of the bronchi causing coughing), pneumonia (lung infection characterised by fever, malaise, headache), skin and soft tissue infections, non gonoccocal urethritis, impetigo (bacterial infection causing sores on the skin). It acts on the bacteria which causes the above mention bacterial infections caused by the bacteria. It kills completely or slows the growth of these sensitive bacteria in our body. Generic name of Generic Macrosil is Roxithromycin. Macrosil is also known as Roxithromycin, Roximycin, Biaxsig, Roxar, Surlid. Brand name of Generic Macrosil is Macrosil.

Dosage

Macrosil is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.

Overdose

Immediately telephone your doctor or pharmacist. Do this even if there are no signs of discomfort or poisoning.

Storage

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F) away from moisture, light and heat. Do not store in the bathroom. Keep in a tight, light-resistant container. Keep out of the reach of children.

Side effects

The most common side effects associated with Macrosil are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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A monoclonal antibody D51 recognizes the transferrin-receptor structure. Microfluidic devices, which constrain fluids to a small (typically submillimeter) scale, facilitate analysis of platelet function, coagulation biology, cellular biorheology, adhesion dynamics, and pharmacology and, as a result, can be an invaluable tool for clinical diagnostics. Nurse intervention appears to help those with the least knowledge of epilepsy improve their knowledge scores. In EC, G(alphai) directly interacts with SRC and this interaction leads to SRC activation and phosphorylation in a manner that is regulated by beta(2)AR stimulation. Hyper-IgD syndrome and familial Hibernian fever are true periodic fever syndromes. Hemodynamic parameters in patients with acute cervical cord trauma: description, intervention, and prediction of outcome. Action of cortisone on the levels of hepatic iron in the rabbit of both sexes.

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Among the mechanisms suggested for the prothrombotic activity of lupus anticoagulant and antiphospholipid antibodies is the direct inhibition of the anticoagulant activated protein C (APC) pathway. Large scale subfractionation of THP-1 cells determined that while cytoplasmic lipid droplets constituted much of the total NMR-visible lipid, the contribution of DRMs was significant. Refuelling by migratory birds before take-off on long flights is generally considered a two-phase process, with protein accumulation preceding rapid fat deposition. Analycys: a database for conservation and conformation of disulphide bonds in homologous protein domains. TAS in all samples was determined by spectrophotometric and enzyme-linked immunosorbent assay methods.We studied the possible association of the TAS level with various clinical indices relevant to POAG. The primary objective of this paper was to determine the extent and nature of interspecies differences in axon calibre and myelin sheath thickness and in the various relationships between these. Home range size in mammals is a key ecological trait and an important parameter in conservation planning, and has been shown to be influenced by ecological, demographic and social factors in animal populations. The method also detects the presence of the CYP21A1P/CYP21A2 chimeric gene.

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Individuals carrying high-risk alleles of both rs6502867 and rs2670660 had an odds ratio of 4.20 compared with individuals carrying a high-risk allele from only one signal. Neurodevelopmental outcome of infantile spasms: A systematic review and meta-analysis. From an Utstein database, we assessed survival to admission and comorbidity with the Charlson comorbidity index from the National Patient Registry and employment status from the Danish Rational Economic Agents Model database. Health status assessment tool for the family member caregiver of patients with bipolar disorder: development and psychometric testing. The Experimental Inoculation of Foxes with Formalized Tissue of Infected and of Healthy Ferrets During an Epizootic. The appendix and cecum were mobilized, and the tip of the appendix was anastomosed directly to the skin of the right lower quadrant through 1 of the 5 mm. We validate the predicted target regions of Grainyhead by ChIP-seq and identify this factor as a general cofactor in the eye network, being bound to thousands of nucleosome-free regions. Reactive Intermediates on Metal Surfaces: A Ketene Monolayer on Single Crystal Platinum Generated by Photolysis of Pyridyl alpha-Diazoketones This research was supported financially by the Natural Science and Engineering Research Council of Canada (NSERC), The University of Western Ontario ADF, and the Canadian Foundation for Innovation. Intravenous magnesium in the treatment of hydrofluoric acid burns in rats.

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To ensure blinding, O group patients received 10 ml placebo-saline i.v. The notion that cells of the immune system possess glycogen and use it as an energy source has not been widely explored. Three independent reviewers assessed the methodologic quality and extracted data for each trial. A novel immunosuppressive agent FTY720 induced Akt dephosphorylation in leukemia cells. The structure of pulmonary valves transplanted to the systemic circulation evolved toward that of normal aortic valves. The tumor was very aggressive with early and widespread metastases in regional and other lymph nodes, soft tissues, various parts of the skeleton, bone marrow, lungs. Association of personality, neighbourhood, and civic participation with the level of perceived social support: the HUNT study, a cross-sectional survey. Exposure to beta-naphthoflavone and benz(a)anthracene resulted in a higher copy number of IL-1 alpha and IL-6 mRNA while lower level of IL-1 beta mRNA was detected in these cells. A cholinergic model synapse to elucidate protein function at presynaptic terminals. In dense stratified systems such as microbial mats, photosynthesis and respiration are coupled due to a tight spatial overlap between oxygen-producing and -consuming microorganisms.

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Repeat courses of ACS did not correlate to adverse cardiovascular risk profile in adolescence and young adulthood, but long-standing effects on the arterial tree and glucose metabolism, the latter dependent on GA at ACS exposure, cannot be excluded. Longitudinal course and clinical significance of TGF-beta1, sL- and sE-Selectins and sICAM-1 levels during severe acute stress in children. Lymphocytic hypophysitis is a rare inflammatory disorder which is caused by autoimmune destruction of the pituitary gland. The interpretation of recently published phase III cancer trials by their authors or by editorialists was not influenced by financial relationships or industry sponsorship. In addition, A2AR is downregulated and desensitized in the maternal heart, suggesting a differential modulation of these receptor-mediated pathways by caffeine. Fluoxetine improves functional work capacity in women with premenstrual dysphoric disorder.

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