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Lekoklar (Clarithromycin)
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Lekoklar

Lekoklar is used in the treatment of infections caused by bacteria. The infections may include pneumonia, respiratory tract infections,lyme disease,strep throat,skin infections, H. pyloriinfection, among others. It is categorised as an broad-spectrum antibiotic which protects against mycoplasma,chlamydiaand mycobacteria and other gram-negative and gram-positive bacteria. It works by decreasing protein production of these bacteria. It is available in the form of tablets, pills and liquids.

Other names for this medication:
Bicrolid, Ciclinil, Cidoclar, Clacina, Clacine, Clarithromycin, Claritrox, Clariva, Claromac, Claryl, Claxid, Cleanomisin, Emimycin, Euromicina, Gervaken, Glartin, Heliclar, Helimox, Infex, Kailasa, Klabet, Klarigen, Klariger, Klarimac, Klarithrin, Kleromicin, Laricid, Lyoclar, Macladin, Monozeclar, Quedox, Rolicytin, Synclar, Taclar, Veclam

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Also known as: Clarithromycin

Description

Lekoklar (generic name: clarithromycin; brand names include: Maclar / Klaricid / Klacid / Clarimac / Claribid) is used to treat many different types of bacterial infections affecting the skin and respiratory system, including: Strep throat, Pneumonia, Sinusitis (inflamed sinuses), Tonsillitis (inflamed tonsils), Acute middle ear infections, Acute flare-ups of chronic bronchitis.

It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. It is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

It also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), crypotosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Lekoklar works by stopping the growth of or killing sensitive bacteria by interfering with their protein synthesis.

Dosage

The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Lekoklar Filmtab and Lekoklar Granules are recommended as the primary agents. Lekoklar Filmtab and Lekoklar Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Lekoklar is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Lekoklar therapy should continue if clinical response is observed. Lekoklar can be discontinued when the patient is considered at low risk of disseminated infection.

Overdose

Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.

Storage

Store Lekoklar XL Filmtab at 20 to 25 degrees C (68 to 77 degrees F). Excursions permitted to 15 to 30 degrees C (59 to 86 degrees F).

Side effects

The most common side effects associated with Lekoklar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Lekoklar if you are allergic to its components or to clarithromycin or to similar medicines such as azithromycin (Zithromax), dirithromycin (Dynabac), erythromycin (E.E.S., E-Mycin, Ery-Tab, Erythrocin), troleandomycin (Tao). Do not take Lekoklar if you're pregnant or you plan to have a baby, or you are a nursing mother. Do not take Lekoklar if you take astemizole (Hismanal), cisapride (Propulsid), ergot medicine such as ergotamine (Ergomar, Ergostat, Cafergot, Ercaf, Wigraine), or dihydroergotamine (D.H.E. 45, Migranal Nasal Spray), pimozide (Orap), terfenadine (Seldane). Do not take Lekoklar if you have liver disease, kidney disease, myasthenia gravis, porphyria; personal or family history of "Long QT syndrome". Try to be careful with Lekoklar usage in case you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Avoid consuming alcohol. It can be dangerous to stop Lekoklar taking suddenly.

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Prevalence and impact of renal insufficiency on clinical outcomes of patients undergoing coronary revascularization. (S)-7c exhibited an overall partial androgenic effect but full anabolic effect via oral administration in castrated rats. Progression of autoimmune diabetes driven by avidity maturation of a T-cell population. The clinical presentation of this lesion with facial palsy sparing emotion-related movement has rarely been described and offers a clue for exploring the neuroanatomy of facial movement. T1-weighted and T2-weighted image sets with a volume resolution of 1 mm(3) and fluid-attenuated inversion-recovery image sets with a volume resolution of 3 mm(3) were obtained in acquisition times of less than 10 minutes per image set. Changes in TBV were closely related in time to changes in both right (RAA) and left (LAA) atrial area and in plasma i-ANP concentrations. A pharmacokinetic interpretation of increasing concentrations of DEHP in haemodialysed patients. To observe the effect of SiO2 nanoparticles on genome DNA methylation profile in cultured cells.

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The subjects were patients aged 60-85 years with nonpsychotic unipolar major depression not attributed to dementing disorders, medical illnesses, or drugs causing depression and had a 24-item Hamilton Depression Rating Scale score of 18 or greater. New trends in the use of chorionic gonadotropin levels in the diagnosis and prognosis of pregnancy. These devices employ a unique ionically conductive polymer that enables the required electric field gradient to be established. We present, compare and contrast the availability and functionality of different important features of NMA in these three packages so that clinical investigators and researchers can determine which R packages to implement depending on their analysis needs. The effect of two hallucinogenic agents on human retinal function. and Verongula gigantea) using a wide array of techniques (Fourier transform infrared (FTIR), Raman, X-ray, Calcofluor White Staining, Immunolabeling, and chitinase test), we show that chitin is a component of the outermost layer (cuticle) of the skeletal fibers of these demosponges. The effect of inhibitors on the phosphorylation of the proteins, the identified sites of phosphorylation, and in vitro phosphorylation by recombinant Akt further indicated that pp47, 105, and 250 are likely to be Akt substrates, whereas pp75 may not be. The midsagittal area of the cerebrum, corpus callosum, midbrain, cerebellar vermis, and vermal lobules VI and VII was measured by means of magnetic resonance imaging in 22 boys with low-functioning autistic disorder and in 11 age-matched normal controls. Further refinement of testing methods and an increase in the number of analyzed samples are required for formal statistical analysis and further determination of clinical relevance in different nasal subtypes. First, some similar significant trends were found across surveys.

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The cultivation conditions that supported growth and differentiation of neural stem cells were optimal for in vitro developmental studies and the production of oligodendroglial cells. A small-diameter, actively deflectable flexible ureteroscope was recently employed in clinical trials at two university centers. Other intermediates such as nitric oxide (NO), specific cleocin medication uses microRNAs (miR), and transcriptional and post-translational modification have also been implicated as players in ROS mediated HIF-1a regulation. Our results show that the two vectors developed in this study are useful for functional gene analysis using an HTP-screening system on a genome-wide scale. Conditional tetracycline-regulated expression of TGF-beta1 in liver of transgenic mice leads to reversible intermediary fibrosis. LH analog and dietary isoflavones support ovarian granulosa cell tumor development in a spontaneous mouse model. Fundus blood flow was estimated using a laser Doppler flowmetry. The supernatant from monocytes stimulated with LPS from Escherichia coli, J-5 strain, selectively potentiated ECF production, whereas that from Salmonella minesota potentiated MCF production.

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For many persons who wish to obtain the health benefits provided by dietary n-3 fatty acids, daily ingestion of fish or fish oil is not a sustainable long-term approach. One-year results of simultaneous laser in situ keratomileusis and small-aperture corneal inlay implantation for hyperopic presbyopia: comparison by age. This function of alpha(IIb)beta(3) depends upon a transition from a resting to an activated state such that it acquires the capacity to bind soluble ligands. cholerae O1 isolated from environmental objects that necessitates a more rational and effective use of antibacterial preparations, determination of antiobioticogram for every isolated culture, strict bacteriologic control during the course of etiotropic therapy for the prevention of increase of number of resistant strains. The mortality of Boophilus annulatus, Hyalomma excavatum, Rhipicephalus bursa, and Rhipicephalus sanguineus adult ticks was recorded after their exposure in petri dishes to 5 entomopathogenic nematode strains. These findings suggest that 3-NP-induced neuronal degeneration in corticostriatal slices results from apoptosis that in the cortex can be prevented by creatine, while in the more vulnerable striatal cells it may lead to an accelerated and increased execution of apoptotic cell death, preventing further necrosis-related damage in this region.

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These results indicate that GH acts as a gonadotrophin to stimulate testosterone and oestradiol secretions by Leydig cells, and that it modulates LH or T3 induced secretion of these steroids, depending on the intensity of their stimulation. We use mosaic-based MARCM techniques to analyze the role of these genes in the persistent larval neuroblasts and progeny of the central brain and thoracic ganglia. Liver iron stores were decreased and blood was present in stool, indicating that the anemia was due to blood loss. Interlayer dissection of the atrial septum resulting in the formation of a cavity developed after an attempted repair of a mitral paraprosthetic leak. Additionally, in patients the earlier N1 ERP component was diminished when the precue signalled either the symptomatic or asymptomatic hand. Oral health is determined by diet, oral hygiene practices, and the pattern of dental visits. Transcranial magnetic stimulation (TMS) studies have suggested that callosal afferents may mediate inhibition of the ipsilateral motor cortex (IMC) during unilateral hand movements. We also describe basic acquisition methods used in BOLD fMRI and associated artifacts. We present a density functional calculational study to clarify that a 3(10)-helix peptide can serve as a novel dual-relay element to mediate long-range charge migrations via its C- and N-termini in proteins.

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Prothrombin activation represents the key regulatory step in the hemostatic process. The as-prepared 3D hierarchical nanostructures possess a high surface area of 77 m(2) g(-1) with pore diameters of ca. The overall quality of evidence was considered to be low for this review, given that five of the seven studies provided low or very low quality evidence. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. Potential role of WISP3 (CCN6) in regulating the accumulation of reactive oxygen species. Inspired by organ culture-induced changes in the vascular endothelin (ET) receptor cleocin capsules population, we investigated whether such changes occur in cerebral arteries in a rat subarachnoid hemorrhage (SAH) model. Juvenile and aged mice underwent a similar protocol, and cardiac sections were harvested for measurement of fibrosis.

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Using this technique, CED can be used to safely perfuse targeted regions of diseased brainstem with therapeutic agents. Other 38 patients who underwent eradicative operation were prospectively randomized to sufentanil anesthesia and fentanyl anesthesia. Attempts to increase the clavulanic acid synthesis by manipulating the anaplerotic flux on C(3) and C(5) precursors by supplementing the medium with arginine, ornithine, proline, valine, leucine, isoleucine, pyruvic acid and alpha-ketoglutarate were successful. Our results show that the slow resorption of the graft particles did not jeopardize the osseointegration of the implant. Although cement augmented screws and Schuhli augmentation showed increased fixation stability compared with cleocin 150 mg 4 times a day the standard screws in axial and 4-point bending before cycling (range, 1.3-1.4 times greater), this was not significant. The results showed that the biosorption of bivalent metal ions to H. Administration of exogenous type I IFNs was sufficient to suppress arthritis. An unpublished injury pattern in a consecutive series of 13 elite boxers is described, with mid-term radiological and functional results of two novel surgical treatments.

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This new virus, designated Four Corner virus, has been further characterised and seems to be closely related to Puumala virus that causes nephropathia epidemica (hemorrhagic fever with renal syndrome) in Scandinavia and Central Europe. Pulsed magnetic fields accelerate cutaneous wound healing in rats. A protein identified as a Cl-stimulated cellobiosidase was repressed in S85 cells growing on glucose and further repressed in the mutants, while a cellulose-binding protein identified as pilin was unchanged in S85 grown on glucose but was not produced by the mutants. Further research is warranted to establish the relative importance of endurance training for improving repeated-sprint performance in AFL football. In conjunction with CDKL5 phosphorylation assay, this approach detected a protein band with an apparent molecular mass of 120kDa that is remarkably phosphorylated by CDKL5. Fas-associated factor 1 plays a negative regulatory role in the antibacterial immunity of Locusta migratoria. Finally, we draw the conclusion that photochromic compounds can only be used as optical limiters if the time constant for the back photochemical reaction is slow compared to the pulse duration. Inhibitory effect of menaquinone-7 (vitamin K2) on the bone-resorbing factors-induced bone resorption in elderly female rat femoral tissues in vitro. If so, this would suggest that the nest works as an incubation chamber (but which now may serve more than one function). There was an appreciation of the importance of developing increased awareness and utilisation of CAM in medical practice, as well as a recognition of resistance by some medical school faculty to CAM approaches.

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These results strongly suggest that the carbohydrate moieties of the cell surface containing the beta-adrenoceptor molecule may have a crucial role in the drug-receptor interaction, and they imply that the beta-adrenoceptor molecule is a glycoprotein which contains N-linked carbohydrate chains. Utility of 320 slice mapping CT for adrenal vein sampling in subjects suspected of having primary-aldosteronism compared with digital-subtraction-angiography and selective retrograde CT adrenal venography. We find that these neurons are specified from the same progenitor neuroblast at two different developmental stages: embryonic and larval neurogenesis. Potassium fluxes in bovine adrenal cells during adrenocorticotropin stimulation. A novel derivatization-based liquid chromatography tandem mass spectrometry method for quantitative characterization of naphthenic acid isomer profiles in environmental waters. The findings revealed five themes: Discovering Stroke, Delaying Treatment, Living with Uncertainty, Discovering the Impact of Stroke, and Reconstructing Life.

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Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial. An approach to phenotyping a transgenic or knockout animal in a reproducible fashion is presented using this convention. A questionnaire study was conducted of workers with a diagnosis of work-related skin disease. We found the expression of the mRNAs encoding NGF, brain-derived neurotrophic factor (BDNF), and trk-b, which is the receptor molecule of BDNF in mouse osteoblastic MC3T3-E1 cells. A 60-year-old male was referred to our hospital for bilateral ureteral stones. Fgf8 expression in nascent mesoderm exiting the primitive streak is dramatically reduced in mutant embryos, and diminished T expression accompanies the progressive loss of sumycin cost paraxial, lateral, and primitive streak mesoderm. Uropathogenic Escherichia coli (UPEC) is the leading cause of urinary tract infections in women, causing significant morbidity and mortality in this population.

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