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Flagenase (Metronidazole)

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Flagenase is a medicine used to treat different types of bacterial and parasitic infections, including those that affect the skin, vagina, blood, heart, bone, stomach, liver, joints, nervous system, respiratory tract, and other areas of the body.

Other names for this medication:
Anabact, Anaeromet, Anerozol, Biozyl, Birodogyl, Collazole, Dumozol, Efloran, Emedal, Filmet, Flagicure, Florazole, Gnostol, Mebadiol, Metris, Metrocev, Metrocream, Metrodal, Metrol, Metrolotion, Metronidazol, Metropast, Metrosil, Molazol, Nidazole, Nizole, Rosaced, Rosasol, Supplin, Trichazole, Tricofin, Trogyl

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Vantin, Sumycin, Cipro, Ilosone, Cleocin, Chloromycetin, Rulide

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Also known as: Metronidazole


Flagenase (generic name: Metronidazole) is an antibiotic that belongs to a group of medicines called nitroimidazoles.

Flagenase is used for the treatment of susceptible anaerobic bacterial and protozoal infections in the following conditions: amebiasis, symptomatic and asymptomatic trichomoniasis; skin and skin structure infections; CNS infections; intra-abdominal infections (as part of combination regimen); systemic anaerobic infections; treatment of antibiotic-associated pseudomembranous colitis (AAPC); bacterial vaginosis; as part of a multidrug regimen for H. pylori eradication to reduce the risk of duodenal ulcer recurrence.


Flagenase 250-mg tablets are round, blue, film coated, with SEARLE and 1831 debossed on one side and Flagenase and 250 on the other side; bottles of 50, 100, and 2,500. Flagenase 500-mg tablets are oblong, blue, film coated, with Flagenase debossed on one side and 500 on the other side; bottles of 50, 100, and 500.


Single oral doses of Flagenase, up to 15 g, have been reported in suicide attempts and accidental overdoses. Symptoms reported include nausea, vomiting, and ataxia. Oral Flagenase has been studied as a radiation sensitizer in the treatment of malignant tumors. Neurotoxic effects, including seizures and peripheral neuropathy, have been reported after 5 to 7 days of doses of 6 to 10.4 g every other day.

There is no specific antidote for Flagenase overdose; therefore, management of the patient should consist of symptomatic and supportive therapy.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed. Talk to your pharmacist about the proper disposal of your medication.

Side effects

The most common side effects associated with Flagenase are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Hypersensitivity. Flagenase Tablets is contraindicated in patients with a prior history of hypersensitivity to metronidazole or other nitroimidazole derivatives. In patients with trichomoniasis, Flagenase Tablets is contraindicated during the first trimester of pregnancy.

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However, it is unknown whether LPS directly affects hepatic stellate cells (HSCs), the main fibrogenic cell type in the injured liver. Increased awareness and understanding of these meanings are important for nurses as they provide health care for this increasing population. Serious complications such as heart failure and hypotension resulting in cardiovascular collapse and death may occur. Nonsteroidal anti-inflammatory drugs may have an adverse effect on outcome. However, little is known about the general mechanisms by which NB-LRR proteins recognize Avr proteins or how they subsequently induce defense responses. We investigate the local thermal activity in the active region by measuring the spectral reflectance change with injection current. Renal failure (RF) is a well-recognized complication of aortic aneurysms (AA) although its incidence has been poorly documented previously. Flexible external fixation for craniodorsal coxofemoral luxations in dogs. into IL-2 receptor gamma-chain disrupted SCID mice, and SCID-PBL/hu mice were constructed.

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Measurement of blood pressure in two different arteries using telemetry system during parabolic flight in rats. The detection limits for the PQQGDH/cyt b(562) and GOD/cyt b(562) electrodes were 0.1 and 0.8 mM, respectively, and their linearity extended to over 2 and 9 mM, respectively. Structural complexes of the eukaryotic translation initiation factor 4E (eIF4E) with a series of N(7)-alkylated guanosine derivative mRNA cap analogue structures have been characterised. BQ123 also normalized CO2 reactivity and improved the functional cerebral blood flow response to somatosensory stimulation. Antisera to the prothoracicotropic (PTTH) and the eclosion (EH) hormones, which in some insects regulate the molting and ecdysis rhythms, respectively, typically react with a few neurons in the frontal protocerebrum. The results revealed that both Adelta- and C-fibres contributed to nociceptive FRA and non-FRA reflex pathways. We evaluated the dark focus of accommodation, referred to as tonic accommodation, in 60 young hyperopic subjects, 20 with and 20 without accommodative esotropia, and 20 with hyperopic anisometropia. Fifty-three healthy volunteers received three different forms of acupuncture in a single-blinded crossover design: superficial needling (0.3 cm), deep needling (2 cm) and needling with bi-directional rotation. The results provide information on the topology of class II bound peptides. The trabecular meshwork, conjunctiva, and retina can each show how oxidative stress may acts as a common disease effector as the Helicobacter infection spreads, supported by the increased oxidative damage and other inflammation.

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To evaluate the efficacy and safety of capecitabine in patients with advanced or recurrent gastric cancer, we conducted a pilot phase II study in Japan. The case of a zoo keeper who was bitten on the left finger by a venomous snake (Vipera xanthina) is reported. Magneto-photoluminescence measurements of individual zinc-blende GaAs/AlAs core/shell nanowires are reported. Expansion of human gamma/delta T cells in vitro is differentially regulated by the measles virus glycoproteins. The Drug Safety Research Unit monitored the safety of these drugs immediately after their launch in England using the non-interventional observational cohort technique of prescription-event monitoring (PEM).

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The detection of mutations is performed supporting by the grant in Czech Republic. The authors through individual interviews have analyzed the way cancer patients got to know about their illness and how these information influenced their lives, family and their feelings. The sequence of reactions leading to the oxy radical-dependent oxidation of ethanol as well as other hydroxyl radical-scavenging agents by these various systems is believed to proceed through the formation of a common intermediate, namely, hydrogen peroxide (H2O2), after dismutation of the superoxide anion radical (O2-.). OCT is a high-resolution intravascular imaging technique that accurately identifies stent struts and arterial tissues. These results indicate that DNA methylation can influence, from a distance, the activity of an unmodified promoter. Female Sprague Dawley rats were ovarectomized (OVX) at age 8 weeks and subsequently maintained on a low-calcium diet for 3 months. The conclusions from these comparisons are that the genetic abundance profiles may provide a foundation for separating and quantifying genetically distinct groups of cyanobacteria in their natural habitats. These findings add new information about the influence of the acid tolerance response on L.

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Its main advantage is its ability to provide initial stability required for osseointegration and proper implant location and parallelism. Hemodynamic responses to cold pressor, speech, and arithmetic stressors were evaluated using impedance cardiography. Results of heparinoid therapy in organic peripheral arteriopathies. Cell viability was unchanged even if observation was extended to 48 h. Achieving pH control in microalgal cultures through fed-batch addition of stoichiometrically-balanced growth media. More thought would need to go into transplantation from a two or three locus-mismatched relative or a mismatched unrelated donor. The extranuclear GR population may exert effect(s) on site in the cytoplasm without involving nuclear genomic transcription. Taken together, the data presented here demonstrate that embryonic and fetal myoblasts represent intrinsically different myogenic lineages and provide important information for the understanding of the molecular mechanisms governing skeletal muscle development. Primers derived from AFLAV sequence were used to screen this retrotransposon in other strains of A. Compared with healthy volunteers, patients with iatrogenic hypoalbuminemia have higher free ceftriaxone concentrations during the 24 h after antibiotic administration.

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Mechanisms by which certain RNA viruses, such as hepatitis C virus, establish persistent infections and cause chronic disease are of fundamental importance in viral pathogenesis. For large mammalian genomes, analyzing oligonucleotide tiling array data is complicated by the presence of non-unique sequences on the array, which increases the overall noise in the data and may lead to false positive results due to cross-hybridization. Many of the indications are empirical, and have either not been proven in controlled studies or are extrapolated from adult studies. The development of a safe, affordable and effective malaria vaccine to form part of control schemes in malaria endemic countries is a priority for researchers and public health officials. Results compare very well with those reported in the literature. Treatment of antibody-mediated accelerated rejection using plasmapheresis. Clinical significance of salicylates in massive upper gastrointestinal bleeding. The present study suggests that CRRT, in patients with SIRS, may promote a decrease in PAI-1 and consequently, a better outcome. A contribution to the familial occurrence of positional anomalies of the testes and malignant degeneration.

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The dynamic of granulocytic macrophages and erythroid precursors content in bone marrow of CBA mice, irradiated by 2.0 Gy and the level of colony-stimulating and erythropoietic activities in supernatant of bone marrow myelocariocytes and blood serum were studied. Distinct, highly organized sub-populations of brainstem NA neurons express oestrogen receptors (ERs) and some of these display species differences. Purpose of this pilot study was to evaluate the effect of adjunctive hyperbaric oxygen therapy (HBO) on visual acuity (VA). Increased diurnal QTe dynamicity is independently predictive of sudden death among patients with myocardial infarction. IL-17A neutralising antibody could inhibit the IL-17A-induced activation of DVSMCs. When compared with our previous study in which only one cycle of cyclophosphamide was given, the double procedure did not increase response rate, decrease the incidence of local relapse, or prolong the relapse-free interval. Nebulization versus injection in ambulatory treatment of acute asthma: a comparative study. Even after pediatric vaccination with PCV-13, vaccine serotypes were still responsible for most pneumonia and invasive disease, underscoring the importance of implementing current guidelines and extending vaccination to other risk groups.

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The developments and considerations essential to providing microtechnological aids for a preschool severely disabled child confined to a bed in a hospital ward are described. A developmentally regulated cysteine proteinase in Dictyostelium discoideum. Laparoscopic resection is expected to increase the number of cases of synchronous gastrointestinal (GI) cancers that meet the indication for laparoscopic surgery, owing to early detection of GI cancers and extended indications for laparoscopic surgery. Chemometrics proved to be superior to traditional attempts of interpreting the spectra. The span of the IC along the anterior-posterior and medial-lateral axes of the OT was variant.

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Furthermore, to study the effects of alpha- and beta-adrenergic receptor stimulation, phenylephrine and isoprenaline were infused locally. Cells of the immune system have recently been recognized as a source of the proopiomelanocortin (POMC)-derived peptides, ACTH and endorphins, and their receptors. Myonecrosis in sickle cell anemia: case report and review of the literature. We hypothesized that facilitating the students to analyze a set of clinical pathology tests by using CHC charts as modules would enhance their integrated approach towards the laboratory data. 3) act as pattern-recognition receptors for the bacterial PAMPs flagellin and elongation factor Tu (EF-Tu) (ref. Expanding the scope of pressure-assisted electrokinetic injection for online concentration of positively charged analytes in capillary electrophoresis-mass spectrometry. In recent years we have described the symbiotic relationship between T vaginalis and Mycoplasma hominis.

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The first type of the dimers leaves the active centre of binase free. Furthermore, parameters were compared with predicted values for lunar and Martian gravities to determine the method that showed the best agreement. The production of SCC antigen is detected from the cells and the amount of SCC antigen in cultured media was recorded from 1.5 to 2.0 ng per 1 x 10(4) cells for 48 hours. The measurement of the protein hormone prolactin (PRL) in biological samples has developed over the years into a routine clinical assay aiding the diagnosis of multiple medical conditions. Additionally, the livers were blindly scored by one observer during two separate assessments longer than 3 months apart. Thus, the latter is to be reserved to very severe veinous ischemia with limb loss threatening where fibrinolytic therapy fails or is contre-indicated. We stained for MIF and iNOS in tissues collected during 44 paediatric autopsies in Blantyre, Malawi. Questionnaire data were supplemented by accompanying narrative responses and several personal interviews. Additionally, a significant voltage-dependent change in the resistance of the gold nanowire array was observed during the controlled formation of the electrical double layer. Because these components are likely to be present simultaneously in the atherosclerotic milieu, we investigated whether oxLDL interacts with FGF-1 and whether this interaction affects FGF-1 functioning.

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This article presents and tests a group-level model of safety climate to supplement the available organization-level model. In this study, the in vitro activities of the A/S and AUG were evaluated and compared against Escherichia coli and Klebsiella spp. Indications for transplant were chronic liver failure (1 case), encephalopathy without liver insufficiency (2 cases), an adenoma (1 case), a liver mass (1 case). This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas. The etiology and epidemiology of tako-tsubo cardiomyopathy remain uncertain. To investigate the prevalence and the prognostic impact of chronic obstructive pulmonary disease (COPD), in patients hospitalised with chronic heart failure (CHF). Histological and ultrastructural examination, gamma picturing and isotope scanning with 99mTc were done in group 1 at 2 PBH. The results were consistent with those from Experiment 1 and showed that word recognition is an attention-demanding process and that the demands are inversely related to the number of meanings of the stimulus.

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Phase I will use a quantitative cross-sectional design and Phase II a qualitative descriptive approach. Here, we provide a technical description and an assessment of the optimizations included in Tomo3D to take advantage of AVX instructions. A channel between the anterior humeral cortex and anterior musculature is created, and an arthroscope is introduced through a proximal lateral portal at the lateral aspect of the channel. Out of 107 blood samples, 92 were analysed based on the quality of the sequencing data. Distinct DNA-binding properties of the high mobility group domain of murine and human SRY sex-determining factors. It enables the patients with diabetes to detect blood glucose with a glucose oxidase electrode independently at home. The present case is remarkable for the nodular superficial cerebellar lesions and the absence of intracranial contrast enhancement of the leptomeninges. Improved survival following injection sclerotherapy for esophageal varices: final analysis of a controlled trial. RNA interference (RNAi) is a sequence-specific post-transcriptional gene silencing process.

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We show that, because of its metabolism by 11-HSD2, corticosterone is a poor activator of MR transactivation, except at micromolar concentrations, where the enzyme is saturated. Mathematical modeling of viral kinetics: a tool to understand and optimize therapy. Rab8, a member of the Rab family of small GTPases, plays an important role in membrane trafficking from the trans-Golgi network and recycling endosomes to the plasma membrane. We assume a multinomial distribution of multiple endpoints with Dirichlet priors and apply the Bayesian test of noninferiority to the calculation of weighting parameters. We hypothesize that recurrent passage of biliary sludge may precipitate obstructive inflammation and fibrosis of the ampulla of Vater. Potential role of ATP-binding cassette transporters against acaricides in the brown dog tick Rhipicephalus sanguineus sensu lato. Aging in an infinite-range Hamiltonian sumycin drug classification system of coupled rotators.

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The aim of the present study was to investigate whether intracerebroventricular (i.c.v.) injection of VIP and PACAP acts in a similar or different manner to affect body temperature and energy expenditure in the domestic chick. Correlative circadian rhythms of cholecystokinin and dopamine content in nucleus accumbens and striatum of rat brain. The aim of this longitudinal study was to verify the effect of seated and supine positions on spatio-temporal parameters of reaching in 4-6-month-old infants. A revised interpretation of human corneal nerve architecture is presented based on recent observations obtained by in vivo confocal microscopy (IVCM), immunohistochemistry, and ultrastructural analyses of serial-sectioned human corneas. Oral naltrexone as a treatment for relapse prevention in formerly opioid-dependent drug users: a systematic review and economic evaluation. Given the likelihood of an inhospitable prebiotic atmosphere on early Earth, it is possible that impact processes of comets or other icy bodies were a source of prebiotic chemical compounds on the primitive planet. Patients allergic to grass pollens were randomly assigned to one of the three treatment groups and followed up to 2 weeks during the peak of the pollen season. Modification of environmental factors and body weight may minimize calcium oxalate urolith formation and recurrence. Vitamin E also attenuated LysoPC-induced MCP-1 expression in GEC. An orphan gyrB in the Mycobacterium smegmatis genome uncovered by comparative genomics.

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Genetic changes occurring in established tumors rapidly stimulate new antibody responses. Synthesis of copper nanoparticles by electrolysis of DNA utilizing copper as sacrificial anode. The roxithromycin 150 mg reduction of aminoglycoside activity may have implications for the common failure of these antibiotics in the treatment of pulmonary infections caused by MPA in cystic fibrosis patients, but must be considered only an in-vitro phenomenon at present. Urinary and plasma homocysteine and cysteine levels during prolonged oral N-acetylcysteine therapy. We have previously shown that FOXM1c can transactivate its target genes by two different mechanisms, depending on the FOXM1c binding site. Robotic technology has emerged as a promising alternative to laparoscopic techniques. Abstracts of the Latin American Committee for Treatment and Research in Multiple Sclerosis. Reverse transcriptase polyemrase chain reaction was used to establish ratios of BCR-ABL:ABL mRNA in peripheral blood cells and plasma, and absolute levels of BCR-ABL mRNA per unit volume of plasma.

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In some cases, regionalisation may be the only economically viable way to organise specialist care. Host resistance influences patterns of experimental viral adaptation and virulence evolution. Insulin-like growth factor binding protein-6 inhibits the growth of human bronchial epithelial cells and increases in abundance with all-trans-retinoic acid treatment. FPC and PC2 are found to completely or partially colocalize at the plasma membrane and the primary cilium and can be reciprocally coimmunoprecipitated. Immune therapy for acute myeloid leukaemia (AML) has been largely disappointing. Introduction to six short papers on the ceftin antibiotic dosage present status of clinical hemodialysis. Regulation of choline kinase activity and phosphatidylcholine biosynthesis by mitogenic growth factors in 3T3 fibroblasts. Research shows that pedestrians, similar to drivers, experience reduced situation awareness, distracted attention and unsafe behavior when talking or texting on their mobile phones. Control over the hydrogen atom transfer reactivity and selectivity through solvent polarity and hydrogen bonding. In order to fully understand the relationship between host and virus, it is important to study the effect of virus infection in all regions of the world.

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Following a well-defined gonadotropin rise with initiation of LH-RH treatment, no further response was noted. Overcoming penicillin failures in the treatment of Group A streptococcal pharyngo-tonsillitis. Recombinant human GR (rhGR) bound in a concentration-dependent manner to in vitro transcribed MCP-1 mRNA, whereas other members of the steroid hormone receptor family did not. Degradation and mineralization of DDT by the ectomycorrhizal fungi, Xerocomus chrysenteron. Cervical disease was assessed using Papanicolaou smears, colposcopy, and biopsies when necessary. The mechanism of this hyporesponsiveness is multifactorial but may be explained in part by activation of the intrarenal RAA system as well as by a reduction in renal perfusion pressure. The ED(50) and ED(95) for spinal ropivacaine in lower limb surgery of 50 min duration or less were 7.6 and 11.4 mg, respectively. FK506 was administrated into Wistar/ST rats intraperitoneally for 7 days. The association between alcohol consumption and the risk of chronic kidney biaxin 500 mg disease (CKD) has been reported. Functional and structural age-related changes in the scalp skin of Caucasian women.

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To research the hereditary stability of Dendrobium huoshanense which were subcultured 7-8 times in the same tissue culture system. Systemic stem cells transplanted into the kidney protected against unilateral ureteral obstruction-induced renal epithelial-mesenchymal transition and renal fibrosis. HLA-DRB1 first domain sequences of two new DR11 alleles and one novel DR4 allele. Qualitative content analysis for emerging themes in letters written by graduating medical students to patients during a Capstone Course. Large cell neuroendocrine carcinoma of the lung: radiologic and pathologic findings. Characterization of novel precursor miRNAs using next generation sequencing and prediction of miRNA targets in Atlantic halibut. PRL enhanced urine production and decreased urine osmolarity and sodium concentration. While the number of new HCV cases is declining, the rates of HCV-associated morbidity and mortality are increasing. Limitations of O2-CO2 graphic analysis applied to gaseous phenomena. Preparation and characterization by surface-enhanced infrared absorption spectroscopy of silver nanoparticles formed on germanium substrates by electroless displacement.

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We aimed to define the characteristics of patients with 46XX CAH but having fully developed male external genitalia. Effects of urinary bladder distension on activity of T3-T4 spinal neurons receiving cardiac and somatic noxious inputs in rats. Recurrent instability of the hip in the absence of an identifiable cause is a challenging problem. All patients but one vaccinated with VSV lysates of autologous melanoma cells developed antibodies against VSV, and all patients vaccinated with VSV lysates of SK-MEL-13 developed antibodies against HLA-related antigens. The experiments demonstrate the advantages of using process-dissociation procedures over comparisons between direct and indirect tests. The chosen parameter to evaluate the demineralization capability was solute flux. The histologic examination of the surgical specimen, which led to the diagnosis of an intraparenchymal necrotic focus, confirms the favourable result of the adjuvant therapy. On average, velocity of sway is higher in older subjects compared with younger subjects, and the difference between young and old is greater with dynamic posturography than with static posturography. However, the limited number of tissues represented in the EST data as well as the different cDNA construction protocols noroxin medication may influence the predictive capacity of ESTs to unravel tissue-specifically expressed transcripts. The reaction products of NS protein were almost the same as those of N protein with the exception that diffuse background staining was observed.

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One common consequence of genetic ablation of FGF signaling, beta1-integrin or laminin gamma1 chain expression in ES cells is is biaxin related to penicillin the absence of laminin-1, which correlates with failure of BM assembly and epiblast differentiation. Endometrial carcinoma recurring as carcinosarcoma: report of two cases. There was a trend towards a greater increase in specific IgA among the subjects receiving the vaccine in combination with Lactobacillus GG. In this study, autologous serum testing was found to highly positive in chronic urticaria patients with HP IgG antibody, but the relationship between autoimmunity and HP infection requires further investigations. Asymptomatic carrier of hepatitis B virus--implication and mechanism of the occurrence. 6) Mature taste buds with alpha-gustducin-immunopositive cells were observed at E18, and their numbers increased gradually with age. Nitrergic function is lost but endothelial function is preserved in the corpus cavernosum and penile resistance arteries of men after radical prostatectomy.

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