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Dorolid (Roxithromycin)
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Dorolid

Dorolid (generic name: roxithromycin; brand names include: Roximycin / Biaxsig / Roxar / Surlid) belongs to a class of drugs known as semi-synthetic macrolide antibiotics. Dorolid is used for the treatment of bacterial infections including infections of the ear, nose and throat, respiratory tract, skin and skin structure infections, and urinary tract infections.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Bazuctril, Biaxsig, Bicofen, Biostatik, Cadithro, Claramid, Crolix, Delos, Dorolid, Elrox, Erybros, Floxid, Infectoroxit, Klomicina, Ladlid, Macrolid, Macrosil, Makrodex, Monobac, Nirox, Odonticina, Pedilid, Pedrox, Renicin, Ritosin, Rokilide, Rokithrid, Roksimin, Roksolit, Rolexit, Rolicyn, Romyk, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxitromicina, Rulid

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Also known as: Roxithromycin

Description

Dorolid is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Dorolid is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Dorolid is available under several brandnames. Dorolid is not available in the United States. Dorolid is available in Australia, Israel and New Zealand. Dorolid has also been tested to possess antimalarial activity.

Dorolid prevents bacteria from growing, by interfering with their protein synthesis. Dorolid binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Dorolid has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Take Generic Dorolid by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Dorolid tablets whole with a glass of water. Generic Dorolid should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Dorolid works best if you take it on an empty stomach. For treating bacterial infections, Generic Dorolid is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Dorolid suddenly.

Overdose

If you overdose Generic Dorolid and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Keep the tablets in the foil until it is time to take them.

Keep the tablets/in a cool dry place where the temperature stays below 30 degrees C.

Do not store Dorolid or any other medicine in the bathroom or near a sink.

Do not leave it in the car on hot days or on window sills.

Heat and dampness can destroy some medicines.

Keep it where children cannot reach it.

A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Dorolid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Immunohistochemical localization of estrogen receptors in the ovine corpus luteum throughout the estrous cycle. Skull base structures were observed using both an operating microscope and a rigid endoscope. Influence of initial pesticide concentrations in water on chlorpyrifos toxicity and removal by Iris pseudacorus. Isokinetic evaluation of muscular performance: implications for muscle testing and rehabilitation. The release of acetylcholine (ACh) from instantly frozen Torpedo electric organ synaptosomes in the course of stimulation is systematically associated with an increase in the number of large intramembrane particles counted on freeze-fracture replicas. As such, these enzymes are critical regulators of signal transduction pathways that use cyclic nucleotides as second messengers. Transcellular ion currents and extension of Neurospora crassa hyphae. Furthermore, and no less importantly, the toxicity of CPPs depends heavily on peptide concentration, cargo molecule and coupling strategy. These results suggest that anti-CD3 mAb can be utilized for the enhancement of anti-tumor responses in vivo and may have general application in the treatment of immunodeficiency. The highest stress in the model with contact interface is higher than that in the bonded model.

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