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Clarimycin (Clarithromycin)
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Clarimycin

Clarimycin is an antibiotic used to treat various types of infections. It is effective in most infections of the respiratory tract, ear, nose, throat, lungs, and skin. It is also effective against a bacteria known as H. pylori, which is associated with peptic ulcer disease.

Other names for this medication:
Althromicin, Bacterfin, Biclar, Ciclinil, Cidoclar, Clacina, Clacine, Clamycin, Clarimac, Claripen, Claritab, Clarithromycin, Clariva, Clarix, Clarogen, Claron, Clarosip, Claryl, Clasine, Clormicin, Derizic, Euromicina, Finasept, Gervaken, Helozym, Kalecin, Klabet, Klabion, Klarimax, Klerimed, Kleromicin, Laricid, Larithro, Maclar, Mononaxy, Monozeclar, Onexid, Synclar, Veclam, Xylar, Zeclaren

Similar Products:
Noroxin, Rulide, Avelox, Ceftin, Terramycin, Zithromax, Omnicef, Chloromycetin

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Also known as: Clarithromycin

Description

Clarimycin (generic name: clarithromycin; brand names include: Maclar / Klaricid / Klacid / Clarimac / Claribid) is used to treat many different types of bacterial infections affecting the skin and respiratory system, including: Strep throat, Pneumonia, Sinusitis (inflamed sinuses), Tonsillitis (inflamed tonsils), Acute middle ear infections, Acute flare-ups of chronic bronchitis.

It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection [a type of lung infection that often affects people with human immunodeficiency virus (HIV)]. It is used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers.

It also is used sometimes to treat other types of infections including Lyme disease (an infection that may develop after a person is bitten by a tick), crypotosporidiosis (an infection that causes diarrhea), cat scratch disease (an infection that may develop after a person is bitten or scratched by a cat), Legionnaires' disease (a type of lung infection), and pertussis (whooping cough; a serious infection that can cause severe coughing). It is also sometimes used to prevent heart infection in patients having dental or other procedures.

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

Clarimycin works by stopping the growth of or killing sensitive bacteria by interfering with their protein synthesis.

Dosage

The recommended daily dosage is 15 mg/kg/day divided every 12 hours for 10 days (up to the adult dose). Refer to dosage regimens for mycobacterial infections in pediatric patients for additional dosage information.

For the treatment of disseminated infection due to Mycobacterium avium complex (MAC), Clarimycin Filmtab and Clarimycin Granules are recommended as the primary agents. Clarimycin Filmtab and Clarimycin Granules should be used in combination with other antimycobacterial drugs (e.g. ethambutol) that have shown in vitro activity against MAC or clinical benefit in MAC treatment.

For treatment and prophylaxis of mycobacterial infections in adults, the recommended dose of Clarimycin is 500 mg every 12 hours.

For treatment and prophylaxis of mycobacterial infections in pediatric patients, the recommended dose is 7.5 mg/kg every 12 hours up to 500 mg every 12 hours.

Clarimycin therapy should continue if clinical response is observed. Clarimycin can be discontinued when the patient is considered at low risk of disseminated infection.

Overdose

Overdose symptoms may include severe stomach pain, nausea, vomiting, or diarrhea.

Storage

Store Clarimycin at room temperature, between 68 and 77 degrees F (20 and 25 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Clarimycin out of the reach of children and away from pets.

Side effects

The most common side effects associated with Clarimycin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Concomitant cisapride, pimozide, ergots, HMG-CoA reductase inhibitors extensively metabolized by CYP3A4 (lovastatin or simvastatin). History of QT prolongation or ventricular cardiac arrhythmia (including torsades de pointes). Concomitant colchicine (in renal or hepatic impairment). Cholestatic jaundice/hepatic dysfunction with prior clarithromycin use.

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Electromyography (EMG) onsets of vastus medialis obliquus (VMO), vastus lateralis (VL), tibialis anterior and soleus were assessed before and after the six week standardised treatment programs. EMG activity also increased during a test period, reflecting increased mobilization to maintain performance. Gastrointestinal (GI) motility results from the coordinated actions of enteric neurons, interstitial cells of Cajal (ICC), and smooth muscle cells. Effects of changes in coronary stenosis on left ventricular diastolic filling assessed with pulsed Doppler echocardiography. Comparative evaluation of the VITEK 2, disk diffusion, etest, broth microdilution, and agar dilution susceptibility testing methods for colistin in clinical isolates, including heteroresistant Enterobacter cloacae and Acinetobacter baumannii strains. These conserved B-cell and T-cell epitopes can be helpful in developing effective vaccines against HCV and thus limiting threats of HCV infection in Pakistan. A total of 199 streptococci isolated from feces of healthy chickens, pigs, and beef cattle and 26 human clinical isolates were tested for resistance to kanamycin, streptomycin, tetracycline, erythromycin, and lincomycin. Nine drugs that were granted pediatric exclusivity were selected.

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Tetranectin binds hepatocyte growth factor and tissue-type plasminogen activator. Effects of lithium in vitro levaquin sinusitis dosage on noradrenaline-induced cyclic AMP accumulation in rat cortical slices after reserpine-induced supersensitivity. Letrozole, an aromatase inhibitor, is used frequently in the treatment of oestrogen receptor-positive breast cancer. The effect on lactose production of several external modulators of intracellular cyclic AMP was studied in rat mammary gland tissue slices and explants. In addition, since it has a simple and small drive unit, it does not obstruct surgeon or other surgery robots. The individual, unique tumor Ags, which characterize each single tumor, were described 50 years ago in rodents but their molecular characterization was limited to few of them and obtained during the last 20 years.

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