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Chloramphenicol

Chloramphenicol (brand names include: Chlornitromycin / Chloramphenicol / Fenicol / Phenicol / Nevimycin / Vernacetin / Veticol) is a broad-spectrum synthetic antibiotic. Chloramphenicol is used to treat a wide variety of bacterial infections, including lung and blood infections; infections of the brain including bacterial meningitis and brain abscesses; and infections of the eye, ear or skin.

Other names for this medication:
Chloramphenicol, Chloroptic, Fenicol, Sopamycetin

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Description

Chloramphenicol is used in the treatment of infections caused by bacteria. It works by killing bacteria or preventing their growth.

Chloramphenicol is used to treat serious infections in different parts of the body. It is sometimes given with other antibiotics. However, chloramphenicol should not be used for colds, flu, other virus infections, sore throats or other minor infections, or to prevent infections.

Chloramphenicol should only be used for serious infections in which other medicines do not work. This medicine may cause some serious side effects, including blood problems and eye problems. Symptoms of the blood problems include pale skin, sore throat and fever, unusual bleeding or bruising, and unusual tiredness or weakness. You and your doctor should talk about the good this medicine will do as well as the risks of taking it.

Chloramphenicol is available only with your doctor's prescription.

This product is available in the following dosage forms:

  • Powder for Solution

Dosage

Adults should receive 50 mg/kg/day in divided doses at 6-hour intervals. In exceptional cases patients with infections due to moderately resistant organisms may require increased dosage up to 100 mg/kg/day to achieve blood levels inhibiting the pathogen, but these high doses should be decreased as soon as possible. Adults with impairment of hepatic or renal function or both may have reduced ability to metabolize and excrete the drug. In instances of impaired metabolic processes, dosages should be adjusted accordingly. Precise control of concentration of the drug in the blood should be carefully followed in patients with impaired metabolic processes by the available microtechniques (information available on request).

Pediatric Patients. Dosage of 50 mg/kg/day divided into 4 doses at 6-hour intervals yields blood levels in the range effective against most susceptible organisms. Severe infections (eg, bacteremia or meningitis), especially when adequate cerebrospinal fluid concentrations are desired, may require dosage up to 100 mg/kg/day; however, it is recommended that dosage be reduced to 50 mg/kg/day as soon as possible. Children with impaired liver or kidney function may retain excessive amounts of the drug.

Neonates. A total of 25 mg/kg/day in 4 equal doses at 6-hour intervals usually produces and maintains concentrations in blood and tissues adequate to control most infections for which the drug is indicated. Increased dosage in these individuals, demanded by severe infections, should be given only to maintain the blood concentration within a therapeutically effective range. After the first two weeks of life, full-term neonates ordinarily may receive up to a total of 50 mg/kg/day equally divided into 4 doses at 6-hour intervals. These dosage recommendations are extremely important because blood concentration in all premature and full-term neonates under two weeks of age differs from that of other infants neonates. This difference is due to variations in the maturity of the metabolic functions of the liver and the kidneys. When these functions are immature (or seriously impaired in adults), high concentrations of the drug are found which tend to increase with succeeding doses.

Overdose

Overdosing by the patient is nearly impossible, as Chloramphenicol is administered via IV delivery, however an overdose can still happen. The symptoms of an overdose are likely to include nausea, vomiting, mouth odor or unpleasant taste in the mouth, bone marrow suppression, and diarrhea.

Storage

Keep all medicines out of the reach and sight of children.

Chloramphenicol eye drops (including single-use units) must be kept in a fridge (2 to 8 degrees C).

Chloramphenicol eye ointment should be stored in a cool, dry place, away from direct heat and light.

Throw away the bottle or tube of chloramphenicol after you have finished the five-day course of treatment, even if there is some left. Never keep opened bottles or tubes to use later.

Single-use units should be used as soon as the unit is opened. Do not store or re-use opened units for subsequent doses. This is because the units do not contain any preservative.

Side effects

The most common side effects associated with Chloramphenicol are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

If your symptoms do not improve within a few days, or if they become worse, check with your doctor.

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Fruits maturing during floods, despite being fish- or water- dispersed were extensively used by the parrots. In the present data set, the addition of the PFTs or 6MWT did not increase the ability of the dosimetric parameters to predict for acute symptomatic RP. We used dendrochronological methods to reconstruct defoliator outbreaks and fire occurrence at ten sites along a longitudinal transect running from central Oregon to western Montana. The LXA4 and fMLP effects were dose dependent, with a maximum at 100 nM (which caused 2.7- and 2.3-fold increases of 51Cr release, respectively, relative to buffer-treated controls). Fanconi anaemia (FA) is a multisystemic disorder with ocular implications. Modeling and characterization of a nanoliter drug-delivery is cleocin an antibiotic MEMS micropump with circular bossed membrane. The optimal treatment for bleb-related infections is evolving, but consensus is that a high degree of vigilance and aggressive treatment are key to minimizing the potentially blinding nature of this complication.

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The aim of this study was to evaluate the value of lung ultrasound in the diagnosis of respiratory distress syndrome (RDS) in newborn infants. Medical records of 100 patients aged 61 to 94 (mean, 78) years who underwent internal fixation with cancellous screws for undisplaced femoral neck fractures were reviewed. Exposure of intact cells to proteinase K cleaved the 270-kDa SprA into several large peptides, suggesting that it is partially exposed on the cell surface. In a cued version of the water maze task, eNOS-/- and control mice did not differ, implying that the superior performance of eNOS-/- animals on the former tasks cannot be attributed solely to differences in sensorimotor capacities. Medical provisions to planetary missions take in a wide spectrum of medical, engineering and organizational issues the goal of which is to provide good living conditions for humans in space, and to ensure physical and psychic health and performance of crew members during research activities on the Martian surface and soon after return to Earth. The role of viscosity estimation for oil-in-gelatin phantom in shear wave based ultrasound can biaxin treat sinus infection elastography. We tentatively attribute this outcome to the accumulation of conditionally neutral mutations in genes affecting the carbon concentration mechanism.

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