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Bazuctril (Roxithromycin)
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Bazuctril

Bazuctril is a semi-synthetic macrolide antibiotic. It is a white crystalline powder. Bazuctril is very slightly soluble in water, freely soluble in acetone, in alcohol and in methylene chloride. It is slightly soluble in dilute hydrochloric acid.

Other names for this medication:
Acevor, Azuril, Biaxsig, Bicofen, Cadithro, Claramid, Crolix, Dorolid, Elrox, Erybros, Infectoroxit, Ladlid, Macrosil, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Renicin, Ritosin, Rokithrid, Roksimin, Roksolit, Rolicyn, Rolid, Romac, Romyk, Rossitrol, Rotramin, Roxithromycin, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin

Description

Bazuctril is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Bazuctril is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Bazuctril is available under several brandnames. Bazuctril is not available in the United States. Bazuctril is available in Australia, Israel and New Zealand. Bazuctril has also been tested to possess antimalarial activity.

Bazuctril prevents bacteria from growing, by interfering with their protein synthesis. Bazuctril binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Bazuctril has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Take Generic Bazuctril by mouth with food. If you have trouble swallowing the tablet whole, it may be crushed or chewed with a little water. Swallow Generic Bazuctril tablets whole with a glass of water. Generic Bazuctril should be taken at least 15 minutes before food or on an empty stomach (i.e. more than 3 hours after a meal). Generic Bazuctril works best if you take it on an empty stomach. For treating bacterial infections, Generic Bazuctril is usually taken for 5 to 10 days. If you want to achieve most effective results do not stop taking Generic Bazuctril suddenly.

Overdose

Symptomatic treatment should be provided as required. There is no specific antidote.

Storage

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Bazuctril are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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The half-life of the RPS16B transcript, an ARE-like sequence-containing Pub1 target, is decreased in both nab2-1 and nab2-67 mutants. Integration of augmented reality and assistive devices for post-stroke hand opening rehabilitation. To describe duties for Norwegian physicians working in two different OHS models: internal and external. An experimental model was utilized to examine the physiological effects of nonsteroidal anti-inflammatory compounds on locally induced inflammatory lesions in laboratory rabbits. Altogether, these results suggest that high levels of serotonin, acting through 5-HT2 receptors, have neuroprotective action on cortical neurons by controlling Bcl-X(L) mRNA levels and that this action is independent of trkB signaling. Multiple-object tracking among individuals with Down syndrome and typically developing children. In contrast, the molecular mass from conventional plots for high molecular mass samples were much lower than those from SEC/MALLS, even when high ionic strength buffers were used.

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A granulomatous liver abscess which developed after a toothpick penetrated the gastrointestinal tract: report of a case. Total laparoscopic hysterectomy, vaginal hysterectomy and total abdominal hysterectomy using electrosurgical bipolar vessel sealing technique: a randomized controlled trial. Changes of serum thymidine kinase in children with acute leukemia. Focused ethnography was used to explore oral health beliefs and practices, and factors related to child oral health promotion with community members. Recrudescence of various types of tuberculosis should alert the clinician to the possibility of tuberculous pericarditis. We carried out karyometric analysis with 3000X magnification and the measurement of 200 cells from one sample. Due to recent developments in modern interventional cardiology for the majority of patients with multi-vessel disease an indicatory and therapeutical grey-zone between bypass surgery and coronary angioplasty has arisen.

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Furthermore, an attempt is made to demonstrate evidence-based information concerning the design of effective PAP protocols. n., Trichodina jadranica Haider, 1964 and Trichodina raabei Lom, 1962. Differential diagnosis with tumours of hematopoietic and non-hematopoietic nature is described. Percutaneous repair of aortic paravalvular regurgitation can help avoid the need for repeat valve surgery. On the basis of the results obtained, July might be proposed as the most suitable month for harvesting T. Antineoplastic and antibacterial activity of some mononuclear Ru(II) complexes. The NODS total score correlated moderately with gambling behavior and outcome as predicted. The study will be implemented as a 2-parallel group randomized controlled trial in 104 patients with renal or prostate cancer on oral anti-cancer medications over a 3-month study period. The purpose of this study was to investigate the effect of Hcy on the interaction between dendritic cells (DCs) and endothelial cells (ECs) by upregulating the expression of DC-specific ICAM-3-grabbing nonintegrin (DC-SIGN) in cultured DCs. Relatively small doses of exercise should be recommended as an aid to managing cigarette cravings and withdrawal symptoms.

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