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Asmetic (Roxithromycin)
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Asmetic

Asmetic is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Asmetic is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Biaxsig, Bicofen, Biostatik, Cadithro, Claramid, Crolix, Delos, Dorolid, Elrox, Erybros, Floxid, Infectoroxit, Klomicina, Ladlid, Macrolid, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Remora, Renicin, Ritosin, Rokilide, Roksimin, Roksolit, Rolexit, Rolid, Romac, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin

Description

Asmetic is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Asmetic is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Asmetic is available under several brandnames. Asmetic is not available in the United States. Asmetic is available in Australia, Israel and New Zealand. Asmetic has also been tested to possess antimalarial activity.

Asmetic prevents bacteria from growing, by interfering with their protein synthesis. Asmetic binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Asmetic has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.

Dosage

Asmetic is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.

Overdose

Symptomatic treatment should be provided as required. There is no specific antidote.

Storage

Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Asmetic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Cardiac triiodothyronine nuclear receptor binding capacities in amiodarone-treated, hypo- and hyperthyroid rats. The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins. Significance of ballistocardiographic studies in prognosis of myocardial infarct. A baseline postal health survey included details on coffee, tea, milk, soft drink, and chocolate consumption. HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration. However, the ICAM-4 binding region in both I domains seems to overlap with the regions recognized by the ICAM-1 and ICAM-2. They are correlated with elevated serum cholesterol, obesity, and hypertension in children, as well as with a predisposition to premature death from coronary heart disease.

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Polysomnography (PSG), despite limited availability and high cost, is currently recommended for diagnosis of obstructive sleep apnea and titration of effective continuous positive airway pressure (CPAP). Caspase 2 expression was enhanced in the hippocampal neurons in chronic TLE patients. To increase user-friendliness, a frequently used lavage sampler was modified. A subset of stem-like cells from bone marrow that are referred to as marrow stromal cells (MSCs) have been shown to be capable of differentiating into osteoblasts, chondrocytes, adipocytes, myocytes, astrocytes and perhaps neurons. Deficiencies of essential fatty acids, vitamin A and E and changes in plasma lipoproteins in patients with reduced fat absorption or intestinal failure. The structure and the location of the STII gene in clinical isolates of Escherichia coli have been investigated by restriction enzyme analyses. Prior to nephron-sparing surgery of the left kidney an angiography was performed revealing a massive fibromuscular dysplasia. As PGAM1 is a negative transcriptional target of TP53, and is therefore commonly upregulated in human cancers, these findings suggest that Y26 phosphorylation represents an additional acute mechanism underlying phosphoglycerate mutase 1 upregulation. The most active compounds competed for the same binding site as atrazine on PSII.

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The difference in coenzyme specificity was a vital parameter controlling ethanolic xylose fermentation but the XDH/XR ratio was also important. The purpose of this review is to describe the various forms of inflammatory myopathy that occur spontaneously in dogs, and discuss the similarities and differences between inflammatory myopathy in dogs and humans. The study included 50 consecutive patients with mitral stenosis. SHH mediates a number of processes in central nervous system development and is required for the normal induction of ventral cell types in the brain and spinal cord. In addition, recent reassessment of cure criteria have reduced the number of patients considered to be successfully cured.

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Some physiological and psychophysiological signs of neuroticism level in healthy persons. There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine. Metabolic effects and therapeutic applications of triiodothyropropionic acid. Formation of hyaluronan- and versican-rich pericellular matrix by prostate cancer cells promotes cell motility. The authors assessed the functioning of mesolimbic and striatal areas involved in reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder (OCD).

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Cytoplasmic expression of type VII collagen is related to prognosis in patients with esophageal squamous cell carcinoma. Sudden unexpected death in a patient with tumour associated pulmonary embolism. Acupuncture relies on the use of fine needles being inserted into specific points with varying amounts of manual or external stimulation. Therefore, this prospective study was undertaken to evaluate (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting para-aortic lymph nodal metastasis in patients with locally advanced cervical carcinoma when CT findings were negative. This idea is consistent with the diverged combination of AfsA homologues and ArpA homologues in a Streptomyces strain. This contrasts with several other reports showing that an increase in cyclic AMP prior to stimulation enhances release. In addition to maximal medical therapy as for severe colitis including broad spectrum antibiotics, patients with toxic megacolon should be kept nil per os, with small bowel decompression tube (if a small bowel ileus is present) and rotated into the prone or knee-elbow position frequently (evacuation of bowel gas).

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Clinical probability evaluation models in patients with pulmonary thromboembolism. Recent studies have demonstrated a novel molecular mechanism for the regulation of airway smooth muscle (ASM) contraction by RhoA GTPase. Cells were passaged up to eight times and maintained differentiation markers. Elevated expression of stress proteins can be a characteristic of human cancer and may be involved in the development of resistance to some types of chemotherapeutic agent. To report biochemical disease-free survival (bDFS) after conformal brachytherapy with dose escalation to biological target volumes (BTVs) identified by Capromab Pendetide with single photon emission computed tomography and computed tomography image fusion (SPECT/CT). Kinetic studies demonstrated that the mechanism of stimulation is secondary to an increase in the maximal rate of uptake of Na, without an alteration in the affinity of the transporter for Na. High positive predictive value show long term predictive detection possibility. The early postoperative monitorization may supply efficacious information for arrhythmic complications. Following the determination of blood lead levels in children of 8-10 age group, living in selected clean regions of Poland, a statistical analysis of results was carried out.

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Our findings can be interpreted within a predictive coding framework, which characterizes the functional relationship between local and global processing stages, and explains how these stages contribute to the perceptual difficulties associated with ASD. A highly efficient asymmetric hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. The angles of the tooth center lines of the second and third lower molars (48, 47) to the occlusal plane and to one another in 25 orthodontically untreated patients (average age: 16.3 years) were measured and compared with angular values of the patients concerned measured in a dental CT. Flattening filter-free linac improves treatment delivery efficiency in stereotactic body radiation therapy. Here, we describe systematic explorations into the molecular basis ilosone tabletas 500 mg precio farmacia guadalajara underlying hydroxyproline-mediated interstrand interactions on the triple-helical stability of collagen-mimetic peptides containing glutamic acid residues. Estrogen receptor alpha haplotypes and breast cancer risk in older Caucasian women.

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The responsive rate, relapse, adverse reactions and event free survival (EFS) were compared between CSA combined with ATG group and CSA group. In this paper we report that the sequence analysis of the px(2) transcript revealed only one open reading frame (ORF(66)), corresponding to a polypeptide of 66 amino acids. Visceral larva migrans (VLM) and ocular larva migrans (OLM) are two clinical manifestations that result in definable syndromes and present as serious health problems wherever they occur. Using long-wave theory, we derive coupled evolution equations for the free liquid-liquid and liquid-gas interfaces. These results suggest that increased sympathetic nerve activity plays a role in hypertension caused by chronic nitric oxide synthase inhibition and that activation of the renin-angiotensin system in the NTS is involved at least in part in this increased sympathetic nerve activity via AT(1) receptors. Theoretical study of the pyrolysis of methyltrichlorosilane in the gas phase. Defining characteristics are observable signs and symptoms present in the person with the problem.

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At a score of 2, CRAFFT-ADOSPA detects harmful substance use, and at a score higher than or equal to 3 it demonstrates serious substance use. The study population showed improved performance when negotiating stairs and hills, reduced frequency of stumbling and falling, and a preference for the microprocessor control C-Leg as compared with the mechanical control prosthetic knee. Previously, we identified five active phosphatidylinositol ether lipid analogues (PIAs) that target the pleckstrin homology domain of Akt and selectively induce apoptosis in cancer cells with high levels of Akt activity. Prediction of near-room-temperature quantum anomalous Hall effect on honeycomb materials. Interaction between albumin-bound dinitrosyl iron complexes and reactive oxygen species. Furthermore, infection leads to attenuation of transcription of the cellular gene c-fos but not c-myc. Chiropractic management of spondylolisthesis with spondylolysis of the pars interarticularis: an example of the single-case study experimental design. Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells. This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communication disorders, psychiatric disorders, and global functioning. Preparation and microwave absorbing properties of carbon/cobalt ferromagnetic composites.

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