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Asmetic (Roxithromycin)

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Asmetic is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Asmetic is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring.

Other names for this medication:
Acevor, Aristomycin, Asmetic, Assoral, Azuril, Bazuctril, Biaxsig, Bicofen, Biostatik, Cadithro, Claramid, Crolix, Delos, Dorolid, Elrox, Erybros, Floxid, Infectoroxit, Klomicina, Ladlid, Macrolid, Makrodex, Monobac, Nirox, Odonticina, Overal, Pedilid, Pedrox, Ramivan, Remora, Renicin, Ritosin, Rokilide, Roksimin, Roksolit, Rolexit, Rolid, Romac, Romyk, Rossitrol, Rotramin, Roxacine, Roxithromycin, Roxithromycine, Roxithromycinum, Roxitromicina, Rulid

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Also known as: Roxithromycin


Asmetic is a semi-synthetic macrolide antibiotic. It is used to treat respiratory tract, urinary and soft tissue infections. Asmetic is derived from erythromycin, containing the same 14-membered lactone ring. However, an N-oxime side chain is attached to the lactone ring. It is also currently undergoing clinical trials for the treatment of male-pattern hair loss.

Asmetic is available under several brandnames. Asmetic is not available in the United States. Asmetic is available in Australia, Israel and New Zealand. Asmetic has also been tested to possess antimalarial activity.

Asmetic prevents bacteria from growing, by interfering with their protein synthesis. Asmetic binds to the subunit 50S of the bacterial ribosome, and thus inhibits the synthesis of peptides. Asmetic has similar antimicrobial spectrum as erythromycin, but is more effective against certain gram-negative bacteria, particularly Legionella pneumophila.


Asmetic is typically prescribed for a period of 7 to 14 days and patients should take the medication for as long as it has been prescribed to prevent the infection from returning even if they become asymptomatic. Patients should not however, take doses larger than has been prescribed as this can result in an overdose. Overdosing requires immediate medical intervention and may present with symptoms which include abdominal pain, nausea, diarrhea, vomiting, and a general and prolonged feeling of illness.


Symptomatic treatment should be provided as required. There is no specific antidote.


Keep your tablets in the blister pack until it is time to take them. If you take the tablets out of the blister pack they may not keep well.

Keep the medicine in a cool, dry place where the temperature stays below 25 degrees C.

Do not store it or any other medicine in the bathroom, near a sink or on windowsill.

Do not leave it in the car. Heat and damp can destroy some medicines.

Keep it where children cannot reach it. A locked cupboard at least one-and-a-half metres above the ground is a good place to store medicines.

Side effects

The most common side effects associated with Asmetic are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


The safety of roxithromycin has not been demonstrated in patients with impaired hepatic or renal function. Caution should be exercised if roxithromycin is administered to patients with impaired hepatic or renal function. If administered to patients with severe impaired hepatic function (eg. hepatic cirrhosis with jaundice and/or ascites), consideration should be given to reducing the daily dosage to half the usual dosage.

Prolonged or repeated use of antibiotics including roxithromycin may result in superinfection by resistant organisms. In the event of superinfection, roxithromycin should be discontinued and appropriate therapy instituted.

When indicated, incision, drainage or other appropriate surgical procedures should be performed in conjunction with antibiotic therapy.

Antibiotic associated pseudomembranous colitis has been reported with many antibiotics. A toxin produced by Clostridium difficile appears to be the primary cause. The severity of the colitis may range from mild to life threatening. It is important to consider this diagnosis in patients who develop diarrhoea or colitis in association with antibiotic use (this may occur up to several weeks after cessation of antibiotic therapy). Mild cases usually respond to drug discontinuation alone. However, in moderate to severe cases, appropriate therapy with a suitable oral antibacterial agent effective against Clostridium difficile should be considered. Fluids, electrolytes and protein replacement therapy should be provided when indicated.

Roxithromycin, like erythromycin, has been shown in vitro to elicit a concentration - dependent lengthening in cardiac action potential duration. Such an effect is manifested only at supra – therapeutic concentrations. Accordingly, the recommended doses should not be exceeded. In certain conditions macrolides, including roxithromycin, have the potential to prolong the QT interval. Therefore roxithromycin should be used with caution in patients with congenital prolongation of the QT interval, with ongoing proarrhythmic conditions (ie uncorrected hypokalemia or hypomagnesaemia, clinically significant bradycardia), and in patients receiving Class IA and III antiarrhythmic agents.

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Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies. Neuroblastoma is a common pediatric tumor that is derived from improperly differentiated neural crest cells (NCC). A paradigm independent multistage strategy based on the Unsupervised Fuzzy Clustering Analysis (UFCA) and its potential for fMRI data analysis are presented. Follow up study on the immune response to low frequency electromagnetic fields in men and women working in a museum. The tendency to denitrify in the presence of oxygen during growth on chlorobenzene appeared to depend on the oxygen availability and the efficiency to metabolize chlorobenzene under oxygen limitation, which is largely regulated by the activity of the intradiol ring fission dioxygenase. The impact of education status was examined using linear regression controlling for age. These data indicate that NO impairs mucosal healing by inhibiting enterocyte migration through activation of RhoA in a SHP-2-dependent manner and support a possible role for SHP-2 as a therapeutic target in diseases of intestinal inflammation like NEC. Sensitivity, response linearity, reproducibility, and LC compatibility of the interface were thoroughly examined using testosterone, caffeine, a mixture of antiinflammatory drugs, and 3,4-dihydroxybenzoic acid as test compounds. Heart rate reduction due to selective specific inhibition of the If current opens new possibilities in treatment of basic cardiovascular diseases.

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Cardiac triiodothyronine nuclear receptor binding capacities in amiodarone-treated, hypo- and hyperthyroid rats. The mechanism of pore assembly for a cholesterol-dependent cytolysin: formation of a large prepore complex precedes the insertion of the transmembrane beta-hairpins. Significance of ballistocardiographic studies in prognosis of myocardial infarct. A baseline postal health survey included details on coffee, tea, milk, soft drink, and chocolate consumption. HMGB1 protein does not mediate the inflammatory response in spontaneous spinal cord regeneration: a hint for CNS regeneration. However, the ICAM-4 binding region in both I domains seems to overlap with the regions recognized by the ICAM-1 and ICAM-2. They are correlated with elevated serum cholesterol, obesity, and hypertension in children, as well as with a predisposition to premature death from coronary heart disease.

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Polysomnography (PSG), despite limited availability and high cost, is currently recommended for diagnosis of obstructive sleep apnea and titration of effective continuous positive airway pressure (CPAP). Caspase 2 expression was enhanced in the hippocampal neurons in chronic TLE patients. To increase user-friendliness, a frequently used lavage sampler was modified. A subset of stem-like cells from bone marrow that are referred to as marrow stromal cells (MSCs) have been shown to be capable of differentiating into osteoblasts, chondrocytes, adipocytes, myocytes, astrocytes and perhaps neurons. Deficiencies of essential fatty acids, vitamin A and E and changes in plasma lipoproteins in patients with reduced fat absorption or intestinal failure. The structure and the location of the STII gene in clinical isolates of Escherichia coli have been investigated by restriction enzyme analyses. Prior to nephron-sparing surgery of the left kidney an angiography was performed revealing a massive fibromuscular dysplasia. As PGAM1 is a negative transcriptional target of TP53, and is therefore commonly upregulated in human cancers, these findings suggest that Y26 phosphorylation represents an additional acute mechanism underlying phosphoglycerate mutase 1 upregulation. The most active compounds competed for the same binding site as atrazine on PSII.

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Some physiological and psychophysiological signs of neuroticism level in healthy persons. There is a need for high quality randomised controlled trials to evaluate the effectiveness of adjuvant chemotherapy in the management of adenocarcinoma of the small intestine. Metabolic effects and therapeutic applications of triiodothyropropionic acid. Formation of hyaluronan- and versican-rich pericellular matrix by prostate cancer cells promotes cell motility. The authors assessed the functioning of mesolimbic and striatal areas involved in reward-based spatial learning in unmedicated adults with obsessive-compulsive disorder (OCD).

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Cytoplasmic expression of type VII collagen is related to prognosis in patients with esophageal squamous cell carcinoma. Sudden unexpected death in a patient with tumour associated pulmonary embolism. Acupuncture relies on the use of fine needles being inserted into specific points with varying amounts of manual or external stimulation. Therefore, this prospective study was undertaken to evaluate (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) in detecting para-aortic lymph nodal metastasis in patients with locally advanced cervical carcinoma when CT findings were negative. This idea is consistent with the diverged combination of AfsA homologues and ArpA homologues in a Streptomyces strain. This contrasts with several other reports showing that an increase in cyclic AMP prior to stimulation enhances release. In addition to maximal medical therapy as for severe colitis including broad spectrum antibiotics, patients with toxic megacolon should be kept nil per os, with small bowel decompression tube (if a small bowel ileus is present) and rotated into the prone or knee-elbow position frequently (evacuation of bowel gas).

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Clinical probability evaluation models in patients with pulmonary thromboembolism. Recent studies have demonstrated a novel molecular mechanism for the regulation of airway smooth muscle (ASM) contraction by RhoA GTPase. Cells were passaged up to eight times and maintained differentiation markers. Elevated expression of stress proteins can be a characteristic of human cancer and may be involved in the development of resistance to some types of chemotherapeutic agent. To report biochemical disease-free survival (bDFS) after conformal brachytherapy with dose escalation to biological target volumes (BTVs) identified by Capromab Pendetide with single photon emission computed tomography and computed tomography image fusion (SPECT/CT). Kinetic studies demonstrated that the mechanism of stimulation is secondary to an increase in the maximal rate of uptake of Na, without an alteration in the affinity of the transporter for Na. High positive predictive value show long term predictive detection possibility. The early postoperative monitorization may supply efficacious information for arrhythmic complications. Following the determination of blood lead levels in children of 8-10 age group, living in selected clean regions of Poland, a statistical analysis of results was carried out.

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Presence and expression of human papillomavirus sequences in human cervical carcinoma cell lines. On the first examination there was a statistically significant difference between affected and fellow eye in all response amplitudes, without b/a ratio alteration, and a delay in single-flash cone response and 30-Hz flicker implicit biaxin suspension pediatric dosage time. Central nervous system (CNS) complications occurring early and late after acute measles are serious and often fatal. Further efficacy trials are needed to test the effects of Web support when offered as a part of routine care. Our search revealed only 12 cases reported previously in the English-language literature. An open, single-arm trial was designed to investigate the feasibility of treatment of VL patients with miltefosine in field conditions in 13 centers in Bihar. We report the case of a contralateral sixth nerve palsy following ruptured dissecting VA aneurysm. Those complex elements are part of the genome structure of plants in the Poaceae, especially in the Triticeae, but not of Arabidopsis. A smart city application: a fully controlled street lighting isle based on Raspberry-Pi card, a ZigBee sensor network and WiMAX. The concentration of met-enkephalin in the adrenals increased and that of beta-endorphin in blood did not change.

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Sorocein L shows the same substitution pattern of sorocein M and corresponds to its ketalized derivative. what drug class is cleocin Pulmonary paragonimiasis misdiagnosed as tuberculosis: with special references on paragonimiasis. The result of their complete separation was presented by HPLC chromatograms, DryLab simulated chromatograms and a video scan of TLC plate. Free radical generation and oxidative stress with ageing and exercise: differential effects in the myocardium and liver. However, the influence of the population dynamics on the observations reported has so far been neglected. Protein energy malnutrition constitutes a public health problem, especially in less affluent countries.

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Subjects were 1165 Mexican Americans age 65 and over who were administered CLOX as part of the third wave of the Hispanic Established Population for Epidemiological Study (HEPESE) conducted from 1998 to 1999. A smaller number of acini in polar fox lobules enables the central regulation mechanisms to intensify the control of local ventilation. Distortion of the anterior part of the interhemispheric fissure: significance and implications for prenatal diagnosis. Premelanosome-negative inflammatory angiomyolipoma of liver with expression of cathepsin K and TFE3. In contrast, koinophilia allowed sex to persist, even when males represented half the population. Standard intracellular stimulating and recording techniques including voltage-clamp were used to analyze the synaptic responses mediated by two identifiable histamine-containing neurons (HCNs), designated C2 neurons, located in bilaterally symmetric clusters of the isolated cerebral ganglion of Aplysia california. Light-microscopical lectin-binding studies were carried out in healthy and pathologically altered synovial tissue (osteoarthrosis, rheumatoid arthritis (RA)). Plasmid mediated amikacin resistance in clinical isolates of Pseudomonas aeruginosa.

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Our findings can be interpreted within a predictive coding framework, which characterizes the functional relationship between local and global processing stages, and explains how these stages contribute to the perceptual difficulties associated with ASD. A highly efficient asymmetric hydrogenation of cyclic imines containing a pyridyl moiety was established by using iridium catalysts with chiral spiro phosphine-oxazoline ligands. Role of methionine adenosyltransferase 2A and S-adenosylmethionine in mitogen-induced growth of human colon cancer cells. The angles of the tooth center lines of the second and third lower molars (48, 47) to the occlusal plane and to one another in 25 orthodontically untreated patients (average age: 16.3 years) were measured and compared with angular values of the patients concerned measured in a dental CT. Flattening filter-free linac improves treatment delivery efficiency in stereotactic body radiation therapy. Here, we describe systematic explorations into the molecular basis ilosone tabletas 500 mg precio farmacia guadalajara underlying hydroxyproline-mediated interstrand interactions on the triple-helical stability of collagen-mimetic peptides containing glutamic acid residues. Estrogen receptor alpha haplotypes and breast cancer risk in older Caucasian women.

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The responsive rate, relapse, adverse reactions and event free survival (EFS) were compared between CSA combined with ATG group and CSA group. In this paper we report that the sequence analysis of the px(2) transcript revealed only one open reading frame (ORF(66)), corresponding to a polypeptide of 66 amino acids. Visceral larva migrans (VLM) and ocular larva migrans (OLM) are two clinical manifestations that result in definable syndromes and present as serious health problems wherever they occur. Using long-wave theory, we derive coupled evolution equations for the free liquid-liquid and liquid-gas interfaces. These results suggest that increased sympathetic nerve activity plays a role in hypertension caused by chronic nitric oxide synthase inhibition and that activation of the renin-angiotensin system in the NTS is involved at least in part in this increased sympathetic nerve activity via AT(1) receptors. Theoretical study of the pyrolysis of methyltrichlorosilane in the gas phase. Defining characteristics are observable signs and symptoms present in the person with the problem.

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Prolonged exposure to K5 ultimately led to apoptosis via mitochondrial membrane depolarization and caspase activation in endothelial cells. We analyzed 280 testes and epididymides with the gubernacula of 140 well preserved, fresh human fetuses ranging from 10 to 35 weeks after conception with no detectable congenital malformations and 36 undescended testes of 28 boys 2 to 15 years old (mean age 6.8) who had undergone surgery for cryptorchidism. We present a series of 15 patients (16 cases) who presented with pain related to the iliopsoas tendon. The South Australian couples sildenafil study: double-blind, parallel-group randomized controlled study to examine the psychological and relationship consequences of sildenafil use in couples. Damage to the helical cartilage caused by the piercing gun may also have contributed to this infection. Stabilization of cleocin 600 mg IGFBP-1 mRNA by ethanol in hepatoma cells involves the JNK pathway. Symptoms of fatigue in chronic heart failure patients: clinical and psychological predictors. This atypical case illustrates that, in the presence of fever, renal failure, rhabdomyolysis and thrombocytopenia, leptospirosis should be considered, even in the absence of jaundice or meningitis, especially if there is a history of contact with carrier animals. Effects of intra-nasally administered testosterone on sexual proceptive behavior in female capuchin monkeys (Cebus apella). Previous single-dose crossover studies have established therapeutic equivalence of formoterol when administered at the same nominal dose via a dry powder inhaler (DPI) or pressurized hydrofluoroalkane (HFA) metered-dose inhaler (pMDI).

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At a score of 2, CRAFFT-ADOSPA detects harmful substance use, and at a score higher than or equal to 3 it demonstrates serious substance use. The study population showed improved performance when negotiating stairs and hills, reduced frequency of stumbling and falling, and a preference for the microprocessor control C-Leg as compared with the mechanical control prosthetic knee. Previously, we identified five active phosphatidylinositol ether lipid analogues (PIAs) that target the pleckstrin homology domain of Akt and selectively induce apoptosis in cancer cells with high levels of Akt activity. Prediction of near-room-temperature quantum anomalous Hall effect on honeycomb materials. Interaction between albumin-bound dinitrosyl iron complexes and reactive oxygen species. Furthermore, infection leads to attenuation of transcription of the cellular gene c-fos but not c-myc. Chiropractic management of spondylolisthesis with spondylolysis of the pars interarticularis: an example of the single-case study experimental design. Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells. This study aimed to analyze the prevalence of vocal changes in abused children and adolescents, through auditory-perceptual analysis of voice and the study of the association between vocal changes, communication disorders, psychiatric disorders, and global functioning. Preparation and microwave absorbing properties of carbon/cobalt ferromagnetic composites.

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While experimental studies have provided a broad understanding of the physiological and anatomical role of neural elements, a comprehensive description of how the nervous system acquires and processes information is still lacking. New fluorescent tools for watching nanometer-scale conformational changes of single molecules. We conclude that coarse wheat bran used as the only treatment in IBS does not provide a sufficient effect in a 6-week period. Based on the examinations carried out it has been found that intravenous administration of 1 g of Chelation essentially increases the urinary excretion of lead and amoxil to buy zinc, thus lowering their content in blood. Mitochondrial ATPase subunit 6 and cytochrome B gene variations in obese Turkish children. Modifications of the genital tract of female embryos from double chicken eggs. We present what we believe to be a new application of scanning holographic microscopy to superresolution. The present study examines in 10 days old male and females rats whether these differences result from sexual differentiation of the brain, or acute effects of male and female gonadal hormones.

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