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Amoksicilin (Amoxicillin)
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Amoksicilin

Amoksicilin is used to treat infections caused by bacteria in different parts of the body. The active ingredient is amoxicillin. This belongs to a group of medicines called penicillin. Antibiotics help treat bacterial infections that may be too strong for the body's immune system to clear. The two drugs are very similar.

Other names for this medication:
Alfamox, Aloxyn, Amoclen, Amopen, Amoram, Amoxi, Amoxicillinum, Amoxypen, Bimoxan, Bristamox, Cipmox, Clamoxyl, Gimalxina, Hidramox, Hydramox, Larotid, Moxicillin, Ospamox, Penamox, Penimox, Polymox, Raylina, Reloxyl, Servamox, Sintedix, Solciclina, Stacillin, Velamox, Zimox

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Duricef, Zithromax, Myambutol, Amoxil, Vantin, Sumycin, Noroxin

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Also known as: Amoxicillin

Description

Amoksicilin is one of the best forms of antibiotic available today. It is used to treat infections caused by certain bacteria, including: infections of the ear, nose, and throat (pneumonia, bronchitis); infections of the genitourinary tract; infections of the skin and skin structure; infections of the lower respiratory tract; gonorrhea, acute uncomplicated (ano-genital and urethral infections) in male and females.

Amoksicilin is also used before some surgery or dental work to prevent infection. It is also used in combination with other medications to eliminate H. pylori, a bacteria that causes ulcers. Amoksicilin may also be used for other purposes not listed here.

Amoksicilin acts by inhibiting the synthesis of bacterial cell wall and stopping the growth of bacteria.

Amoksicilin is available in capsules.

Amoksicilin is usually taken every 8 hours (three times a day). It can be taken with or without food.

The chewable tablets should be crushed or chewed thoroughly before they are swallowed. The tablets and capsules should be swallowed whole and taken with a full glass of water.

Take Amoksicilin exactly as directed. Do not take more or less Amoksicilin or take it more often than prescribed by your doctor. Do not stop taking Amoksicilin without talking to your doctor. To clear up your infection completely, continue taking Amoksicilin for the full course of treatment even if you feel better in a few days. Stopping Amoksicilin too soon may cause bacteria to become resistant to antibiotics.

Dosage

Children and Adolescents 2 years and older (standard-dose therapy): 45 mg/kg/day PO in divided doses every 12 hours is the standard dose for children with uncomplicated disease that is mild to moderate in severity who do not attend daycare and who have not been treated with an antimicrobial agent in the previous 4 weeks.

Children and Adolescents 2 years and older (high-dose therapy): 80 to 90 mg/kg/day PO in divided doses every 12 hours (Max: 2 g/dose) is recommended for children in areas with high rates of S. pneumoniae resistance (more than 10%, including intermediate- and high-level resistance).

Children younger than 2 years should be treated with Amoksicilin; clavulanic acid, not Amoksicilin alone.

Overdose

In case of overdosage, discontinue medication, treat symptomatically, and institute supportive measures as required. If the overdosage is very recent and there is no contraindication, an attempt at emesis or other means of removal of drug from the stomach may be performed. A prospective study of 51 pediatric patients at a poison-control center suggested that overdosages of less than 250 mg/kg of Amoksicilin are not associated with significant clinical symptoms and do not require gastric emptying.

Interstitial nephritis resulting in oliguric renal failure has been reported in a small number of patients after overdosage with Amoksicilin.

Crystalluria, in some cases leading to renal failure, has also been reported after Amoksicilin overdosage in adult and pediatric patients. In case of overdosage, adequate fluid intake and diuresis should be maintained to reduce the risk of Amoksicilin crystalluria.

Renal impairment appears to be reversible with cessation of drug administration. High blood levels may occur more readily in patients with impaired renal function because of decreased renal clearance of Amoksicilin. Amoksicilin may be removed from circulation by hemodialysis.

Storage

Store between 20 and 25 degrees C (68 and 77 degrees F) away from moisture and heat. Keep bottle closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Amoksicilin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

A false-positive reaction for glucose in the urine has been observed in patients receiving penicillins, such as Amoksicilin, and using Benedict's solution, Fehling's solution, or Clinitest tablets for urine glucose testing. However, this reaction has not been observed with glucose oxidase tests (e.g., Tes-tape, Clinistix, or Diastix). Patients with diabetes mellitus who test their urine for glucose should use glucose tests based on enzymatic glucose oxidase reactions while on Amoksicilin treatment.

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